Clin Psychopharmacol Neurosci.  2016 Aug;14(3):250-255. 10.9758/cpn.2016.14.3.250.

Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population

  • 1Department of Neurology, Dicle University, Medical Faculty, Diyarbakır, Turkey.
  • 2Department of Medical Genetics, Dicle University, Medical Faculty, Diyarbakır, Turkey.
  • 3Department of Medical Genetics, Medical Faculty, Gazi University, Ankara, Turkey.
  • 4Department of Psychiatry, Afsin State Hospital, Kahramanmaras, Turkey.


OBJECTIVE: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis.
We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (−759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system.
We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group.
This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.


Migraine disorders; Single nucleotide polymorphism; Receptor; serotonin; 5-HT2C; Genetic association studies; Headache
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