J Korean Dent Soc Anesthesiol.  2005 Dec;5(2):101-106. 10.17245/jkdsa.2005.5.2.101.

The Sedative Effects of Submucosal Midazolam in Children

• Lee YE
• Park MK
• Kim YH
• Jung SH
• Baek KW

• KMID: 2345149
• DOI: http://doi.org/10.17245/jkdsa.2005.5.2.101

Abstract

PURPOSE
This retrospective study assessed the effectiveness of submucosal (SM) midazolam (M), oral chloral hydrate (CH), hydroxyzine (H), and nitrous oxide (N) 99 uncooperative pediatric dental patients over 182 sedation sessions.
METHODS
Selection criteria included good medical health (ASA I), from 2 to 6 years of age, uncooperative behavior, and the need for restorations and dental surgery. The children who was administerated with CH, H, N was Group 1 (48 case). The children who was administerated with CH, H, N, M was Group 2 (51 case). All the patients received oral CH (50-70 mg/Kg), H (1 mg/Kg) and N (less than 50%). Additionally the Group 2 received SM midazolam (0.1-0.2 mg/kg). Behavior response was rated as quiet (Q), crying (C), movement (M), or struggling (S) every 5 minutes through operative procedures. Behavior response rating was assigned to Houpt scale of Overall behavior. Data was analyzed using Chi-Square Test.
RESULTS
The Group 2 had more effective (88.2%) than the Group 1 (68.8%)(P = 0.05). Also, vomiting response decreased in the Group 2 (94.4%) than those with oral administration of chloral hydrate alone without SM midazolam (77.1%)(P = 0.05).
CONCLUSIONS
SM midazolam improved the quality of sedation and vomiting response.

Keyword

Chloral hydrate; Conscious sedation; Hydroxyzine; Nitrous oxide; Submucosal midazolam

MeSH Terms

Administration, Oral
Child*
Chloral Hydrate
Conscious Sedation
Crying
Humans
Hydroxyzine
Hypnotics and Sedatives*
Midazolam*
Nitrous Oxide
Patient Selection
Retrospective Studies
Surgical Procedures, Operative
Vomiting
Chloral Hydrate
Hydroxyzine
Hypnotics and Sedatives
Midazolam
Nitrous Oxide