Korean J Gastroenterol.  2016 Jul;68(1):23-28. 10.4166/kjg.2016.68.1.23.

Is a Preoperative Gastrointestinal Endoscopy for Second Primary Cancer Detection in Head and Neck Cancer Necessary? Ten-year Registry Data

Affiliations
  • 1Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea. sgun9139@gmail.com
  • 2Department of Otorhinolaryngology, Hallym University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS
In head and neck squamous cell carcinoma, second primary gastrointestinal tumors are not uncommon. However, it is unclear whether a screening endoscopy is needed for detecting gastrointestinal neoplasm in patients with head and neck cancer. Therefore, we analyzed the prevalence and independent risk factors for second primary gastrointestinal neoplasm in head and neck squamous cell carcinoma.
METHODS
A consecutive series of 328 patients with primary head and neck squamous cell carcinoma that underwent esophagogastroduodenoscopy or colonoscopy were included using our registry. An age- and sex-matched group of 328 control subjects was enrolled. We assessed risk factors of synchronous gastrointestinal cancer.
RESULTS
The prevalence of esophageal cancer with head and neck squamous cell carcinoma was significantly higher than that of the control group (1.5% vs. 0.0%, p=0.011). An age of 54 years or more (OR, 1.033; 95% CI, 1.008-1.059; p=0.009) and male gender (OR, 4.974; 95% CI, 1.648-15.013; p=0.004) were risk factors for concomitant colorectal cancer or adenomas in the head and neck squamous cell carcinoma patients.
CONCLUSIONS
Preoperative colonoscopy can be recommended for detecting synchronous second primary colorectal lesions in head and neck squamous cell carcinoma patients with male sex regardless of age, and esophagogastroduodenoscopy is necessary in all head and neck squamous cell carcinoma patients for detecting esophageal cancer.

Keyword

Head and neck neoplasms; Esophagogastroduodenoscopy; Colonoscopy; Diagnosis

MeSH Terms

Adenoma
Carcinoma, Squamous Cell
Colonoscopy
Colorectal Neoplasms
Diagnosis
Endoscopy
Endoscopy, Digestive System
Endoscopy, Gastrointestinal*
Esophageal Neoplasms
Gastrointestinal Neoplasms
Head and Neck Neoplasms*
Head*
Humans
Male
Mass Screening
Neck
Neoplasms, Second Primary*
Prevalence
Risk Factors
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