J Korean Neuropsychiatr Assoc.
2015 May;54(2):252-256. 10.4306/jknpa.2015.54.2.252.
A Case of Clozapine-Induced Anemia and Thrombocytosis
- Affiliations
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- 1Department of Psychiatry, Seoul National University Hospital, Seoul, Korea.
- 2Department of Psychiatry, St. Andrews Neuropsychiatric Hospital, Icheon, Korea. hansonpark@snu.ac.kr
- 3Department of Anthropology, College of Social Science, Seoul National University, Seoul, Korea.
- KMID: 2343906
- DOI: http://doi.org/10.4306/jknpa.2015.54.2.252
Abstract
- Clozapine is a well-known antipsychotic which causes hematologic adverse effects, specifically neutropenia and agranulocytosis (1-3% of patients). However, reports on blood dyscrasias like anemia and thrombocytosis after clozapine treatment are extremely rare. In some cases re-challenge of clozapine could lead to hematopoietic abnormality related to thrombocytopenia or thrombocytosis, which may be a result of an immune reaction. This case report suggests that clinicians should monitor platelet count after re-treatment with clozapine.
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