J Korean Neuropsychiatr Assoc.
2000 Sep;39(5):955-959.
Oxybutynin Hydrochloride in 3 Cases of Clozapine Induced Nocturnal Enuresis
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Chungnam National University, Taejeon
Abstract
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Nocturnal enuresis has been recognized as an adverse effect of clozapine treatment. We reported 3 chronic schizophrenic patients who had showed nocturnal enuresis following clozapine treatment. Oxybutynin hydrochloride on clozapine-induced enuresis was very effective in 3 patients. The dose in our patients was 5 to 10mg/day. This medication was well tolerated. It is suggested that oxybutynin hydrochloride is a effective therapeutic option in clozapine-induced nocturnal enuresis.