J Korean Neuropsychiatr Assoc.  2013 Sep;52(5):327-333.

Influences of Stress, Anxiety, Depression, and Personality Trait on Nausea, Vomiting, and Retching of Breast Cancer Patients Receiving Chemotherapy

• Bhan YW
• Choi HY
• Lim WS
• Moon BI
• Paik NS
• Lim WJ

Abstract

OBJECTIVES
The aim of this study was to identify influences of stress, anxiety, depression, and personality trait on nausea, vomiting, and retching of breast cancer patients perceiving chemotherapy.
METHODS
Breast cancer patients who were admitted to Ewha Womans University Cancer Center for women to receive chemotherapy participated in the study. In addition to sociodemographic and clinical factors, self-reported questionnaires, including Type D personality Scale 14, Hospital Anxiety and Depression Scale, and Global Assessment of Recent Stress scale were used to evaluate psychological factors of the subjects. For examination of anticipatory and post chemotherapy nausea, vomiting, and retching, the subjects filled out the Rhodes Index of Nausea, Vomiting, and Retching and Visual Analogue Scale.
RESULTS
No significant influence of type D personality, anxiety, or depression on nausea, vomiting, and retching was observed. If the patient experienced more severe stress, higher scores for anticipatory and post chemotherapy nausea, vomiting, and retching were recorded. The tendency was retained after adjusting for the cycle number of chemotherapy, the emetic risk of the chemotherapy regimen, type D personality, anxiety, and depression. Specifically, financial problems, unusual happenings, ordinary daily stress, and general stress were significantly related to nausea, vomiting, and retching.
CONCLUSION
Assessment of life stress, especially for financial problems, unusual happenings, and ordinary daily stress of patients receiving cancer chemotherapy can be used as an effective way to reduce the risk of nausea, vomiting, and retching related during chemotherapy.

Keyword

Chemotherapy; Breast neoplasms; Anticipatory vomiting; Stress

MeSH Terms

Anxiety*
Breast Neoplasms*
Breast*
Depression*
Drug Therapy*
Female
Humans
Nausea*
Surveys and Questionnaires
Stress, Psychological
Vomiting*
Vomiting, Anticipatory

Reference

1. Index.go.kr [hompage on the Internet]. Korea: National Statistical Office;Updated 2013 Jan 29. Available from: http://www.index.go.kr.

2. Kim SW, Lee SY, Kim JM. Depression in cancer patients. Korean J Biol Psychiatry. 2006; 13:59–69.

3. Kwon SJ. A recommendation of antiemetics. Korean J Clin Oncol. 2006; 2:30–35.

4. Oh CY, Yun HY, Lim EH, Kim ON. Evaluation of antiemetic therapy after the administration of high-dose antineoplastic agents: focused Ondansetron. J Korean Soc Health Syst Pharm. 1999; 16:495–500.

5. Kim YJ, Kim JY, Choi IR, Kim MW, Rhodes V. The index of nausea, vomiting, retching(Korean Translation). J Korean Acad Adult Nurs. 2000; 12:278–285.

6. Kris MG, Hesketh PJ, Somerfield MR, Feyer P, Clark-Snow R, Koeller JM, et al. American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006. J Clin Oncol. 2006; 24:2932–2947.

7. Kwon SJ. Nausea and vomiting treatment in cancer patients. Korean J Clin Oncol. 2007; 3:23–26.

8. Morrow GR, Roscoe JA, Hickok JT, Andrews PR, Matteson S. Nausea and emesis: evidence for a biobehavioral perspective. Support Care Cancer. 2002; 10:96–105.

9. Komen RW, Redd WH. Personality factors associated with anticipatory nausea/vomiting in patients receiving cancer chemotherapy. Health Psychol. 1985; 4:189–202.

10. Aapro MS, Molassiotis A, Olver I. Anticipatory nausea and vomiting. Support Care Cancer. 2005; 13:117–121.

11. Bourdeanu L, Frankel P, Yu W, Hendrix G, Pal S, Badr L, et al. Chemotherapy-induced nausea and vomiting in Asian women with breast cancer receiving anthracycline-based adjuvant chemotherapy. J Support Oncol. 2012; 10:149–154.

12. Choi JY, So HS, Cho IS. Nausea/vomiting and anxiety of hospitalized cancer patients receiving chemotherapy. J Korean Acad Adult Nurs. 2004; 16:211–221.

13. Denollet J, Sys SU, Brutsaert DL. Personality and mortality after myocardial infarction. Psychosom Med. 1995; 57:582–591.

14. Mols F, Thong MS, van de, Roukema JA, Denollet J. Type D (distressed) personality is associated with poor quality of life and mental health among 3080 cancer survivors. J Affect Disord. 2012; 136:26–34.

15. Lim HE, Lee MS, Ko YH, Park YM, Joe SH, Kim YK, et al. Assessment of the type D personality construct in the Korean population: A validation study of the Korean DS14. J Korean Med Sci. 2011; 26:116–123.

16. Zigmond AS, Snaith RP. The hospital anxiety and depression Scale. Acta Psychiatr Scand. 1983; 67:361–370.

17. Oh SM, Min KU, Park DB. A study on the standardaztion of the Hospital Anxiety and Depression Scale for Koreans. J Korean Neuropsychiatr Assoc. 1999; 38:289–296.

18. Linn MW. A global assessment of recent stress (GARS) scale. Int J Psychiatry Med. 1985; 15:47–59.

19. Ko KB, Park JK. Validity and reliability of the Korean version of the global assessment of recent stress scale. Korean J Psychosom Med. 2000; 8:201–211.

20. Rhodes VA, McDaniel RW. The index of nausea, vomiting, and retching: A new format of the index of nausea and vomiting. Oncol Nurs Forum. 1999; 26:889–893.

21. Hesketh PJ. Chemotherapy-induced nausea and vomiting. N Engl J Med. 2008; 358:2482–2494.

22. Dibble SL, Luce J, Cooper BA, Israel J, Cohen M, Nussey B, Rugo H. Acupressure for chemotherapy-induced nausea and vomiting: a randomized clinical trial. Oncol Nurs Forum. 2007; 34:813–820.

23. Morrow GR, Dobkin PL. Anticipatory nausea and vomiting in cancer patients undergoing chemotherapy treatment: prevalence, etiology, and behavioral interventions. Clin Psychol Rev. 1988; 8:517–556.

24. Pedersen SS, Denollet J. Validity of the Type D personality construct in Danish post-MI patients and healthy controls. J Psychosom Res. 2004; 57:265–272.

25. Choi BJ, Park JH, Choe BM, Han S, Kim SH. Factors influencing anxiety and depression in breast cancer patients treated with surgery. J Korean Soc Biol Ther Psychiatry. 2011; 17:87–95.

26. Massie MJ. Prevalence of depression in patients with cancer. J Natil Cancer Inst Monogr. 2004; 32:57–71.

27. Koh KB, Lee SI, Lee JM. Comparison of stress perception and depression between gastric cancer and gastritis patients. Kor J Psychosom Med. 1994; 2:88–97.

28. Kim YJ, Cho IS, So HS. Changes in index of nausea, vomiting, and retching in hospitalized cancer patients undergoing cancer chemotherapy. J Korean Acad Nurs. 2004; 34:1326–1333.

29. Osoba D, Zee B, Pater J, Warr D, Latreille J, Kaizer L. Determinants of postchemotherapy nausea and vomiting in patients with cancer. J Clin Oncol. 1997; 15:116–123.

30. Gard D, Edwards PW, Harris J, Greg M. Sensitizing effects of pretreatmentmeasures on cancer chemotherapy nausea and vomiting. J Consult Clin Psychol. 1988; 56:80–84.