J Korean Neurol Assoc.
1995 Jun;13(2):291-297.
TNFa and Bacterial Meningitis
- Affiliations
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- 1Department of Neurology, Catholic University Medical College, Korea.
Abstract
OBJECTIVE
/BACKGROUND: We evaluate the role of TNFa in the generation of inflammation and the blood-brain barrier damage in the patients with bacterial and aseptic meningitis. Methods : We recruited three groups for analysis - (1) bacterial meningitis (6pati ents) (2) aseptic meningitis (7patients) (3) non-infectious neurologic disease (7patients). CSF and serum were studied for WBC, albumin concentration and TNFa assay by cytolytic method.
RESULTS
TNFa of CSF, and albumin quotient (Qalb: degree of blood-brain barrier damage) in bacterial meningitis groups were significantly higher than those in control groups(TNFa : 163.23+58.17units/ml, p<0.05 & Qalb : 13.75+5.16, p<0.05). TNF ratio(CSF TNF/SerumTNF) was well correlated with albumin quotient(p<0.05, r=O. 96).
CONCLUSIONS
We conclude that TNFa level is higher in bacterial meningitis group than in other groups. TNFa may play a important role in the pathogenetic process of bacterial meningitis, especially in the destruction of blood-brain barrier.
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