- Nusinersen as a Therapeutic Agent for Spinal Muscular Atrophy
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Li Q
- KMID: 2471912
- Yonsei Med J.
- 2020 Apr;61(4):273-283.
- doi: 10.3349/ymj.2020.61.4.273
The reduction of survival motor neuron (SMN) protein causes spinal muscular atrophy (SMA), an autosomal recessive neuromuscular disease. Nusinersen is an antisense oligonucleotide, approved by the FDA, which specifically binds... -
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- Cefepime-induced neurotoxicity
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Lee SJ
- KMID: 2470468
- J Neurocrit Care.
- 2019 Dec;12(2):74-84.
- doi: 10.18700/jnc.190109
Cefepime, a widely used fourth-generation cephalosporin, has been reported to cause neurotoxicity because it crosses the blood-brain barrier. Although cefepime-induced neurotoxicity (CIN) occurs in patients with renal dysfunction administered a... -
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- Regulation of Diabetes: a Therapeutic Strategy for Alzheimer's Disease?
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Ahn KC, Learman CR, Baker GB, Weaver CL, Chung PS, Kim HG, Song MS
- KMID: 2464193
- J Korean Med Sci.
- 2019 Dec;34(46):e297.
- doi: 10.3346/jkms.2019.34.e297
Accumulated evidence suggests that sporadic cases of Alzheimer's disease (AD) make up more than 95% of total AD patients, and diabetes has been implicated as a strong risk factor for... -
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- Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced Damage
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Cho SB, Eum WS, Shin MJ, Kwon HJ, Park JH, Choi YJ, Park J, Han KH, Kang JH, Kim DS, Cho SW, Kim DW, Choi SY
- KMID: 2463716
- Exp Neurobiol.
- 2019 Oct;28(5):612-627.
- doi: 10.5607/en.2019.28.5.612
Aldose reductase (AR) protein, a member of the NADPH-dependent aldo-keto reductase family, reduces a wide range of aldehydes and enhances cell survival by inhibition of oxidative stress. Oxidative stress is... -
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- Cholesterol Metabolism in the Brain and Its Association with Parkinson's Disease
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Jin U, Park SJ, Park SM
- KMID: 2463711
- Exp Neurobiol.
- 2019 Oct;28(5):554-567.
- doi: 10.5607/en.2019.28.5.554
Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the aging population after Alzheimer’s disease (AD). Defects in the lysosomal systems and mitochondria have been suspected to cause... -
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- tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?
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Kim JS
- KMID: 2449893
- J Stroke.
- 2019 May;21(2):160-174.
- doi: 10.5853/jos.2019.00584
Tissue plasminogen activator (tPA) is the only therapeutic agent approved to treat patients with acute ischemic stroke. The clinical benefits of tPA manifest when the agent is administered within 4.5... -
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- Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier
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Gyawali A, Krol S, Kang YS
- KMID: 2447856
- Biomol Ther.
- 2019 May;27(3):290-301.
- doi: 10.4062/biomolther.2019.007
Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of... -
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- Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
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Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY
- KMID: 2447855
- Biomol Ther.
- 2019 May;27(3):283-289.
- doi: 10.4062/biomolther.2018.107
Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are... -
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- C3a Receptor Inhibition Protects Brain Endothelial Cells Against Oxygen-glucose Deprivation/Reperfusion
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Ahmad S, Kindelin A, Khan SA, Ahmed M, Hoda MN, Bhatia K, Ducruet AF
- KMID: 2450214
- Exp Neurobiol.
- 2019 Apr;28(2):216-228.
- doi: 10.5607/en.2019.28.2.216
The complement cascade is a central component of innate immunity which plays a critical role in brain inflammation. Complement C3a receptor (C3aR) is a key mediator of post-ischemic cerebral injury,... -
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- Perspective in Nuclear Theranostics Using Exosome for the Brain
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Hwang DW
- KMID: 2448098
- Nucl Med Mol Imaging.
- 2019 Apr;53(2):108-114.
- doi: 10.1007//s13139-018-00567-6
Owing to its highly biocompatible property as naturally produced nanoscale particle and drug carrying ability, exosome has attracted much interest in the biomedical area. Versatile functions of exosome in biological... -
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- Effects of Intraperitoneal N-methyl-D-aspartate (NMDA) Administration on Nociceptive/Repetitive Behaviors in Juvenile Mice
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Kim S, Kim DG, Gonzales E, Mabunga DF, Shin D, Jeon SJ, Shin CY, Ahn T, Kwon KJ
- KMID: 2442008
- Biomol Ther.
- 2019 Feb;27(2):168-177.
- doi: 10.4062/biomolther.2018.230
Dysregulation of excitatory neurotransmission has been implicated in the pathogenesis of neuropsychiatric disorders. Pharmacological inhibition of N-methyl-D-aspartate (NMDA) receptors is widely used to model neurobehavioral pathologies and underlying mechanisms. There... -
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- Could Management of Blood Pressure Prevent Dementia in the elderly?
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Mogi M
- KMID: 2468633
- Clin Hypertens.
- 2019 ;25(1):27.
- doi: 10.1186/s40885-019-0135-7
BACKGROUND: Hypertension is one of the most relevant risk factors in vascular aging, stroke and vascular dementia (VD). In the elderly, the prevalence of mixed dementia, which consists of Alzheimer’s... -
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- Magnetic Resonance-Guided Focused Ultrasound : Current Status and Future Perspectives in Thermal Ablation and Blood-Brain Barrier Opening
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Lee EJ, Fomenko A, Lozano AM
- KMID: 2434342
- J Korean Neurosurg Soc.
- 2019 Jan;62(1):10-26.
- doi: 10.3340/jkns.2018.0180
Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging... -
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- Brain-Gut-Microbiota Axis in Alzheimer's Disease
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Kowalski K, Mulak A
- KMID: 2433497
- J Neurogastroenterol Motil.
- 2019 Jan;25(1):48-60.
- doi: 10.5056/jnm18087
Disturbances along the brain-gut-microbiota axis may significantly contribute to the pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent cause of dementia characterized by a progressive decline in... -
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- Brain consequences of acute kidney injury: Focusing on the hippocampus
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Malek M
- KMID: 2447176
- Kidney Res Clin Pract.
- 2018 Dec;37(4):315-322.
- doi: 10.23876/j.krcp.18.0056
The high mortality rates associated with acute kidney injury are mainly due to extra-renal complications that occur following distant-organ involvement. Damage to these organs, which is commonly referred to as... -
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- Association between the simultaneous decrease in the levels of soluble vascular cell adhesion molecule-1 and S100 protein and good neurological outcomes in cardiac arrest survivors
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Kim MJ, Kim T, Suh GJ, Kwon WY, Kim KS, Jung YS, Ko JI, Shin SM, Lee AR
- KMID: 2433157
- Clin Exp Emerg Med.
- 2018 Dec;5(4):211-218.
- doi: 10.15441/ceem.17.267
OBJECTIVE: This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and... -
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- Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
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Suh M, Lee DS
- KMID: 2431978
- Nucl Med Mol Imaging.
- 2018 Dec;52(6):407-419.
- doi: 10.1007/s13139-018-0550-9
Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and... -
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- Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G(αs) Protein-coupled Receptor
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Lee N, Sa M, Hong YR, Lee CJ, Koo J
- KMID: 2424731
- Exp Neurobiol.
- 2018 Oct;27(5):365-376.
- doi: 10.5607/en.2018.27.5.365
Medium-chain fatty acids (MCFAs) are mostly generated from dietary triglycerides and can penetrate the blood-brain barrier. Astrocytes in the brain use MCFAs as an alternative energy source. In addition, MCFAs... -
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- Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future
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Jung NY, Chang JW
- KMID: 2423024
- J Korean Med Sci.
- 2018 Oct;33(44):e279.
- doi: 10.3346/jkms.2018.33.e279
Magnetic resonance-guided focused ultrasound (MRgFUS) is a new emerging neurosurgical procedure applied in a wide range of clinical fields. It can generate high-intensity energy at the focal zone in deep... -
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- Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies
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Cuadrado-Godia E, Dwivedi P, Sharma S, Ois Santiago A, Roquer Gonzalez J, Balcells M, Laird J, Turk M, Suri HS, Nicolaides A, Saba L, Khanna NN, Suri JS
- KMID: 2428766
- J Stroke.
- 2018 Sep;20(3):302-320.
- doi: 10.5853/jos.2017.02922
Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients. Based... -
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