J Korean Neurol Assoc.  1994 Sep;12(3):518-526.

Motor Learning Induces c-fos Expression in Mouse Cerebellum

• Kim MH
• Jeon BS

Abstract

OBJECTIVE
. To examine whether cerebellum participates in motor learning and expresses immediate early gene during motor learning. BACKGROUND. There are increasing evidences that cerebellum plays a role in motor learning. Motor learning such as skill is one of long term memory that produces structural changes associated with immediate early gene expression.
METHODS
. We destructed mouse cerebellum surgically and compared the motor performance with normal control by using Rota-Rods test. Motor performance was tested on repeated trials to measure learning. We also measured the c-fos mRNA level in the cerebellum at 0, 30, 60 and 120 minutes of motor learning experiment.
RESULTS
. Motor learning is impaired in the mice with cerebellar lesion. C-fos mRNA level increased in the cerebellum at 30 and 60 minutes during motor learning.

MeSH Terms

Animals
Cerebellum*
Gene Expression
Learning*
Memory
Mice*
RNA, Messenger
RNA, Messenger