J Korean Neuropsychiatr Assoc.  2002 Jul;41(4):630-637.

Association between Dopamine Receptor D4 Polymorphisms and Novelty Seeking Personality Trait in a Korean Population

Affiliations
  • 1Department of Psychiatry, Eumsung Mental Hospital, Chungbuk Province, Korea.
  • 2Department of Neuropsychiatry, Korea University College of Medicine, Seoul, Korea.
  • 3Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Seoul, Korea.

Abstract


OBJECTIVES
We investigated the relationship of personality traits with dopamine D4 receptor(DRD4) exon III polymorphism in a Korean population.
METHODS
We analysed DRD4 exon III 48-bp repeats polymorphism in 173 Korean healthy female adolescents(age=13.88+/-0.29 years) who also completed Temperament and Character Inventory(TCI).
RESULTS
Novelty seeking score of the TCI was significantly higher in the subjects with DRD4 long alleles(>or=5 repeats) compared with the subjects without these(t=2.11, p=0.037).
CONCLUSION
The present study supports the previous reports that long repeats of the DRD4-exon III polymorphism are related with Novelty Seeking personality.

Keyword

Novelty seeking; Polymorphism; DRD4
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