J Korean Neuropsychiatr Assoc.
2002 May;41(3):454-460.
Effect of Mirtazapine in Patients with Posttraumatic Stress Disorder: A Pilot Study
- Affiliations
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- 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Abstract
OBJECTIVE
This study was conducted to evaluate the effects of mirtazapine in patients with posttraumatic stress disorder(PTSD). METHOD: 15 patients who were diagnosed as PTSD were treated with mirtazapine for 8 weeks. Efficacy measurement and side-effects monitoring were performed at baseline, in 4 and 8 week. PTSD and depression were assessed at each follow-up visits using the following measures : Interviewer-Administered Structured Interview for PTSD(SIP), Short PTSD Rating Interview(SPRINT), Impact of Event Scale-Revised(IES-R), The Montgomery Asberg Depression Rating Scale(MADRS).
RESULTS
Significant reduction of SIP, SPRINT, IES-R, and MADRS was observed after 8 weeks administration of mirtazapine. No serious drug-related side effects occurred.
CONCLUSION
The results suggest that mirtazapine may be an effective agent in the treatment of patients with PTSD. More sophisticated study would be necessary.
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