J Korean Oncol Nurs.  2011 Aug;11(2):116-126.

The Meta-Analysis of the Effect of Acupressure for Nausea and Vomiting in Cancer Patients Receiving Chemotherapy

  • 1Department of Nursing, College of Health and Welfare, Kyungwoon University, Gumi, Korea.
  • 2College of Nursing, Keimyung University, Daegu, Korea. jsp544@kmu.ac.kr


This study was to analyze the characteristics and effect size of intervention studies that used acupressure for the control of chemotherapy-induced nausea and vomiting (CINV).
Nine electronic databases including Korea Education Research and Information, the National Assembly Library, KISS, Korea Med, NDSL, PubMed, EBSCO, Cochrane library, and OVID (to December, 2009) were searched. Thirteen studies of randomized controlled trials (RCTs) or controlled clinical trials (CCTs) were selected. Data were analyzed by SPSS/WIN 18.0.
Overall effect size of acupressure was moderate (0.684). Nausea had a moderate effect size (0.770) and nausea and vomiting had a high effect size (0.899). Acupressure using sticker needles had a high effect size (1.368) among finger acupressure, si-acupuncture, and wrist band treatment.
This study suggests that acupressure using sticker needles on the spots of nei-guan, chok-samni and hap-kok can reduce the levels of nausea and vomiting in cancer patients receiving chemotherapy. For improving the reliability of the meta-analysis results, further randomized controlled trials with better study methodology are needed.


Acupressure; Nausea; Vomiting; Chemotherapy; Meta-analysis

MeSH Terms

Clinical Trial


  • Fig. 1 Process of study selection.

  • Fig. 2 Effect size of dependent variables and intervention type.

  • Fig. 3 Effect size difference (error bars indicates 95% Cls).


1. 2009 Statistics report on the cause of death. Statistics Korea. accessed on November 10, 2010. Available at: http://www.kostat.go.kr.
2. Ministry for Health, Welfare and Family Affairs. Annual Report of cancer incidence (2007), cancer prevalence (2007)and survival (1993-2007) in Korea. 2009. Seoul: Ministry for Health, Welfare and Family Affairs.
3. Baek NS. You must know the cancer to win it, From Prevention to Complete Recovery. 1999. Seoul: Hongsin Moon Hwasa;73–78.
4. Kim BJ, Kim YH, Jeon MH, Choi JS. Care for cancer patients, management of symptom. 2000. Seoul: Hyunmoon Press;163–202.
5. Jung KH. The effect of muscle relaxation therapy on nausea, vomiting and anxiety of children with chemotherapy. Korean J Child Health Nurs. 2000. 6:60–68.
6. Choi YH. Effect of P6 acupressure and Korean hand acupuncture on chemotherapy-induced nausea, vomiting and anorexia among cancer patients [dissertation]. 2003. Daegu: Keimyung Univ..
7. Kang MA, Shin YS, Kim YK. The Effect of Acupressure on the Spots of Zoksamli and Sagwan with Si-Acupuncture on Chemotherapy Related Nausea and Vomiting in Patients with Stomach Cancer. Clin Nurs Res. 2004. 10:145–156.
8. Kim EJ. Effects of Nei-Guan acupressure by wrist band on chemotherapy-related nausea and vomiting in patients with liver cancer [dissertation]. 2007. Seoul: Yonsei Univ..
9. Kim YJ. Effects of the Nei-Guan (P6) acupressure on chemotherapy-related nausea and vomiting in patients with lung cancer [dissertation]. 2002. Seoul: Yonsei Univ..
10. Lee KH. Effects of Nei-Guan acupressure on chemotherapy-related nausea and vomiting in patients with ovarian cancer [dissertation]. 2003. Seoul: Yonsei Univ..
11. Shin YH, Kim TI, Shin MS, Juon HS. Effect of acupressure on nausea and vomiting during chemotherapy in postoperative stomach cancer patient. Cancer Nurs. 2004. 27:267–273.
12. Jung ES. Effects of aroma oil inhalation on nausea, vomiting and anorexia in cancer patients receiving chemotherapy [dissertation]. 2002. Daegu: Keimyung Univ..
13. Yang JH. The Effects of Foot Reflexology on Nausea, Vomiting and Fatigue of Breast Cancer Patients Undergoing Chemotherapy. J Korean Acad Nurs. 2005. 35:177–185.
14. East-west nursing research institute. An introdution to oriental nursing. 2000. Seoul: Soomoon Press;312–325.
15. What is Complementary and Alternative Medicine (CAM)? National Center of Complementary Alternative Medicine. accessed on November 10, 2010. Available at: http://nccam.nih./health/whatiscam/.
16. Dibble SL, Chapman J, Mack KA, Shih AS. Acupressure for nausea: results of a pilot study. Oncol Nurs Forum. 2000. 27:41–47.
17. Baek GS. Effects of meridian acupressure therapy using sticker needles for nausea, vomiting and anorexia caused by chemotherapy in cancer patients [dissertation]. 2008. Seoul: KyungHee Univ..
18. Kim YJ. The Effect of meridian acupressure therapy using Sticker needles for nausea, vomiting caused by chemotherapy in the lung cancer patient [dissertation]. 2009. Seoul: Hanyang Univ..
19. Shin HS, Lee SB, Ryu KH. Effects of Nei-Guan Acupressure on Nausea, Vomiting and Anorexia in Gynecological Cnacer Patients Receiving Chemotherapy. J East West Nurs Res. 2009. 15:26–33.
20. Oh SS. Meta-analysis: Theory and Practice. 2009. Seoul: Konkuk University Press;58–186.
21. Seo JY, Park WJ. The meta analysis of trends and the effects of non-pharmacological intervention for school aged ADHD children. J Korean Acad Psychiatr Ment Health Nurs. 2010. 19:117–132.
22. Roscoe JA, Matteson SE, Morrow GR, Hickok JT, Bushunow P, Griggs J, et al. Acustimulation Wrist Bands Are Not Effective for the Control of Chemotherapy-Induced Nausea in Women with Breast Cancer. J Pain Symptom Manage. 2005. 29:376–384.
23. Jones E, Isom S, Kemper K, McLean TW. Acupressure for Chemotherapy-associated Nausea and Vomiting in Children. J Soc Integr Oncol. 2008. 6:141–145.
24. Molassiotis A, Helin AM, Dabbour R, Hummerston S. The effects of P6 acupressure in the prophylaxis of chemotherapy-related nausea and vomiting in breast cancer patients. Complement Ther Med. 2007. 15:3–12.
25. Kim TI, Shin YH, Oh MS. Effect of Acupressure on Nausea-vomiting and Weight Change among Pediatric Cancer Patients Receiving Anti-cancer Chemotherapy. Korean J Child Health Nurs. 2004. 10:98–107.
26. Rhodes VA. Nausea, vomiting, and retching. Nurs Clin North Am. 1990. 24:885–900.
27. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DM, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clin Trials. 1996. 17:1–12.
28. Cubeddu LX, O'Connor DT, Parmer RJ. Plasma chromogranin; a maker of serotonin release and of emesis associated with cisplatin chemotherapy. J Clin Oncol. 1995. 13:681–687.
29. Kim DW. Chimgu Hwqngjeboguam. Acu-Moxa Royal Guide 1. 1999. Seoul: Sunghan and Kim.
Full Text Links
  • JKON
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr