Korean J Adult Nurs.  2014 Jun;26(3):330-340. 10.7475/kjan.2014.26.3.330.

Effects of Auricular Acupressure on Chemotherapy-induced Nausea, Vomiting, and Serum Serotonin Level

  • 1Department of Nursing, Keimyung College University, Daegu, Korea.
  • 2College of Nursing, Keimyung University, Daegu, Korea. jsp544@kmu.ac.kr


The aim of this study was to identify the effects of auricular acupressure on nausea, vomiting and serum serotonin level in gynecological cancer patients with chemotherapy.
The research was a randomized control group pretest-posttest design. Participants were 26 patients for the experimental group, and 26 patients for the control group. Auricular acupressure in Shen men, Occiput, Stomach and Sympathetic points was administered to those in the experimental group. Data were analyzed using chi2-test, t-test, ANCOVA, and repeated measures of ANOVA.
The experimental group had reported significantly lower mean nausea NRS (Number Rating Scale), INVR (Index of Nausea, Vomiting, and Retching), and serum serotonin level than those in the control group.
Results of the study show auricular acupressure is an effective nursing intervention for reducing chemotherapy-induced nausea, vomiting and serum serotonin level of gynecological cancer patients.

MeSH Terms

Drug Therapy


  • Figure 1 Random assignment flow sheet.

  • Figure 2 Changes of nausea and vomiting in experimental group and control group through repeated measures ANOVA.

Cited by  1 articles

Effect of Auricular Acupressure on Nausea, Vomiting, and Retching in Patients with Colorectal Cancer Receiving Chemotherapy
Nayeon Shin, Jummi Park
Korean J Adult Nurs. 2018;30(3):227-234.    doi: 10.7475/kjan.2018.30.3.227.


1. Andrews PL, Naylor RJ, Joss RA. Neuropharmacology of emesis and its relevance to anti-emetic therapy. Support Care Cancer. 1998; 6:197–203.
2. Antonarakis ES, Hain RD. Nausea and vomiting associated with cancer chemotherapy: Drug management in theory and in practice. Arch Dis Child. 2004; 89:877–880.
3. Baek GS. Effects of meridian acupressure therapy using sticker needles for nausea, vomiting and anorexia caused by chemotherapy in cancer patients. Unpublished master's thesis. Seoul: Kyung Hee University;2008.
4. Benjamin PJ, Tappan FM. Tappan's handbook of healing massage techniques: Classic, holistic and emerging methods. 4th ed. Boston: Prentice Hall;2005.
5. Ezzo J, Streitberger K, Schneider A. Cochrane systematic reviews examine P6 acupuncture-point stimulation for nausea and vomiting. J Altern Complement Med. 2006; 12:489–495.
6. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power3.1: Tests for correlation and regression analysis. Behav Res Methods. 2009; 41:1149–1160.
7. Han SH, Kim YH, Seo HS, Hwang GD, Jung HC, Son JH, et al. The study on 5 cases of patient with vomiting and nausea. J Korean Orient Intern Med. 2003; 24:1023–1029.
8. Hesketh PJ. Chemotherapy-induced nausea and vomiting. The New England Journal of Medicine. 2008; 358:2482–2494.
9. Jeon SJ, Kim KM, Kim HK, Park SO, Bae YS, Jo KS, et al. Medical surgical nursing. Seoul: Hyunmoonsa;2009.
10. Kim DY, Camilleri M. Serotonin: A mediator of the brain-gut connection. Am J Gastroenterol. 2000; 95(10):2698–2709.
11. Kim EH, Kim YJ, Lim BV, Jang MH, Chung JH, Kim CJ. Effects of auricular acupuncture on neuronal activities in the brain of sprague dawley rats. J Korean Acupunct Moxibustion Soc. 2001; 18(1):21–28.
12. Kim HJ, Kim HS. Nausea/vomiting and self-care in patients with cancer on chemotherapy. J Korean Acad Fundam Nurs. 2005; 12(2):180–185.
13. Kim YH, Kwon IK, Kim JH, Seol ME, Jeon MH, Ham YH, et al. Cancer symptom management. Seoul: Hyunmoonsa;2011.
14. Kim YJ. The effect of meridian acupressure therapy using sticker needles for nausea, vomiting caused by chemotherapy in lung cancer patient. Unpublished master's thesis. Seoul: Hanyang University;2009.
15. Kim YJ, Seo NS. Effects of progressive muscle relaxation on nausea, vomiting, fatigue, anxiety, and depression in cancer patients undergoing chemotherapy. J Korean Oncol Nurs. 2010; 10:171–179.
16. Kim YJ, Kim JY, Choi IL, Kim MW, Rhodes V. The index of nausea, vomiting, and retching. J Korean Acad Adult Nurs. 2000; 12:278–285.
17. Kim YS, Kim CW, Kim KS. Clinical observations on postoperative vomiting treated by auricular acupuncture. Am J Chin Med. 2003; 31:475–480.
18. Korean Acupuncture & Moxibustion Academy. The acupuncture and moxibustion medicine. Seoul: Jipmoondang;2012.
19. Lee HS, Sung KW, Son BK, Kim SS, Lee HJ, Lee SY. Effects of hand massage through Korean hand acupuncture therapy on nausea, vomiting and anorexia induced by chemotherapy in cancer patients. Clin Nurs Res. 2006; 11:7–19.
20. Lee KJ. Yichim story of Lee Gyeong Je. Seoul: Gimmyoungsa;2004.
21. Ma L. Acupuncture as a complementary therapy in chemotherapy induced nausea vomiting. Proc (Bayl Univ Med Cent). 2009; 22:138–141.
22. Middleton J, Lennan E. Effectively managing chemotherapy-induced nausea and vomiting. Br J Nurs. 2011; 20(17):S7–S8. S10–S12. S14–S15.
23. Ministry of Health and Welfare. National cancer registration statistics 2009. 2012. November. 06, 2013. from: http://www.cancer.go.kr/mbs/cancer/jsp/album/gallery.jsp?spage=1&boardId=31817&boardSeq=179615&mcategoryId=&id=cancer_050207000000#.
24. National Center for Complementary and Alternative Medicine. Exploring the science of complementary and alternative medicine. 2011. November. 06, 2013. from http://nccam.nih.gov/sites/nccam.nih.gov/files/about/plans/2011/NCCAM_SP_508.pdf.
25. Park EJ. The effect of auricular acupressure on sleep, serotonin, TNF-α & IL-6 of hemodialysis patients. Unpublished doctoral dissertation. Jinju: Gyeongsang National University;2007.
26. Park JG, Bang YJ, Ha SH. Oncology. Seoul: Ilchokak;2012.
27. Rhodes VA, McDaniel RW. The index of nausea, vomiting, and retching: A new format of the index of nausea and vomiting. Oncol Nurs Forum. 1999; 26:889–894.
28. Sahmeddini MA, Fazelzadeh A. Does auricular acupuncture reduce postoperative vomiting after cholecystectomy? J Altern Complement Med. 2008; 14:1275–1279.
29. Taspinar A, Sirin A. Effect of acupressure on chemotherapy-induced nausea and vomiting in gynecologic cancer patients in Turkey. Eur J Oncol Nurs. 2010; 14:49–54.
Full Text Links
  • KJAN
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr