J Korean Ophthalmol Soc.  2014 Dec;55(12):1745-1751. 10.3341/jkos.2014.55.12.1745.

Comparison of Wettability for Ocular Prosthesis Depending on Different Kinds of Artificial Tear Eye Drops

Affiliations
  • 1Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea. drkook@ajou.ac.kr

Abstract

PURPOSE
In this study we compared the surface wettability of ocular prosthesis and depositions depending on different types of artificial tear eye drops.
METHODS
The artificial tear eye drops contain sodium hyaluronate (HA) 0.1%, 0.18%, 0.3%, carboxylmethylcellulose sodium (CMC), hydroxymethylcelluose + dextran (HMC), propylene glycol + polyethylene glycol (PG), polysorbate 80 (PS) povidone (Pov) were evaluated. Flat rectangular parallelepiped blocks consisting of polymethylmethacrylate (PMMA) or silicone materials were made. One artificial tear eye drop was applied on the surface of two different blocks of artificial eyes using a 23-gauge needle. Then, the static method contact angle was measured by using a contact angle goniometer. To measure the deposits, a petri dish was covered with 3 mL of artificial tear eye drops and dried for 48 hours at room temperature. Then, the light transmittance at the center of the petri dish was measured to investigate the amount of the residue.
RESULTS
The contact angles of HA 0.1%, 0.18%, 0.3%, CMC, HMC, PG, PS and Pov on PMMA were 78.69degrees, 84.29degrees, 75.46degrees, 80.93degrees, 66.29degrees, 71.26degrees, 58.40degrees and 70.24degrees, respectively. The contact angles on silicone were 53.68degrees, 60.87degrees, 64.46degrees, 62.78degrees, 38.89degrees, 63.58degrees, 30.68degrees and 51.41degrees, respectively. The largest decrease in transparency was observed in the artificial tear eye drops containing HMC.
CONCLUSIONS
The wettability and deposits on the surface of ocular prosthesis can vary based on the components and concentration of artificial tear eye drops. The results from this study should be considered when choosing the right artificial tear eye drops for improving dry eye symptoms in patients wearing ocular prostheses.

Keyword

Anophthalmos; Artificial tear eye drop; Dry eye syndrome; Ocular prosthesis; Wettability

MeSH Terms

Anophthalmos
Dextrans
Dry Eye Syndromes
Eye, Artificial*
Humans
Hyaluronic Acid
Needles
Ophthalmic Solutions*
Polyethylene Glycols
Polymethyl Methacrylate
Polysorbates
Povidone
Propylene Glycol
Silicones
Sodium
Tears*
Wettability*
Dextrans
Hyaluronic Acid
Ophthalmic Solutions
Polyethylene Glycols
Polymethyl Methacrylate
Polysorbates
Povidone
Propylene Glycol
Silicones
Sodium

Figure

  • Figure 1. Two flat rectangular parallelepiped blocks. According to the conventional methods of manufacturing of ocular prosthesis, two blocks have been produced with polymethylmethacrylate (PMMA) or silicone.

  • Figure 2. Measurement of contact angle. The contact angle is an angle formed between the liquid/solid interface and the liquid/vapor interface.

  • Figure 3. Images obtained from a contact angle goniometer. One drop of each artificial tear eye drops was applied on polymethylmethacrylate (PMMA) or silicone block. CMC = carboxylmethylcellulose sodium; HMC = hydroxymethylcelluose + dextran; PG = propylene glycol + polyethylene glycol; PS = polysorbate 80; Pov = povidone.

  • Figure 4. The residues of each artificial tear eye drops in petri dishes. After evaporation, the HMC containing artificial tear eye drops showed the most residues on the petri dish. HA = hyaluronate; HMC = hydroxymethylcelluose + dextran; CMC = carboxylmethylcellulose sodium; PG = propylene glycol + polyethylene glycol; PS = polysorbate 80; Pov = povidone.

  • Figure 5. Transmittance through the residue of artificial tear eye drops. After drying of each eye drop on petri dishes, the transmittance was measured by spectrometer. A double head arrow indicates the visible light wavelength range (330-770 nm). HA = hyaluronate; HMC = hydroxymethylcelluose + dextran; CMC = carboxylmethylcellulose sodium; PG = propylene glycol + polyethylene glycol; PS = polysorbate 80; Pov = povidone.


Cited by  1 articles

Prosthesis Care in Long-term Prosthetic Eye Wearers
Hyun Yeon Kim, Keun Hae Kim
J Korean Ophthalmol Soc. 2019;60(3):217-222.    doi: 10.3341/jkos.2019.60.3.217.


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