J Korean Ophthalmol Soc.  2014 Aug;55(8):1167-1173.

Change in the mGC-IPL in Patients with a History of APAC According to SD-OCT

• Lee HS
• Park YS
• Park SW

Abstract

PURPOSE
This study was conducted to measure macular ganglion cell-inner plexiform layer (mGC-IPL) thickness in patients with a history of unilateral single attack of acute primary angle closure (APAC) and to compare it with that of unaffected fellow eyes 8 weeks after resolution using spectrum domain optical coherence tomography (SD-OCT).
METHODS
Medical records of 24 patients with history of first episode of unilateral APAC were reviewed retrospectively. Eight weeks after APAC, mGC-IPL thickness and peripapillary retinal nerve fiber layer thickness were measured with SD-OCT and analyzed in eyes affected by APAC (group 1) and fellow eyes (group 2).
RESULTS
There were no significant differences between the groups with regard to best corrected visual acuity, spherical equivalent, central corneal thickness, or axial length (p > 0.05). There were no significant differences in mGC-IPL thickness in the superotemporal, superior, or superonasal sectors (p > 0.05). However, average, inferonasal, inferior, and inferotemporal sectors of group 1 were significantly thinner than those of group 2 (p = 0.002, 0.002, 0.001, 0.001, respectively). In addition, average mGC-IPL difference between affected eyes and fellow eyes showed a statistically significant correlation with attack duration (correlation coefficient = 0.249, p = 0.019).
CONCLUSIONS
Normalization of elevated intraocular pressure as soon as possible after APAC onset is recommended in order to reduce mGC-IPL loss, and measurements of mGC-IPL thickness can be helpful for follow-up of APAC patients.

Keyword

Acute primary angle closure; Ganglion cell-inner plexiform layer

MeSH Terms

Follow-Up Studies
Ganglion Cysts
Humans
Intraocular Pressure
Medical Records
Nerve Fibers
Retinaldehyde
Retrospective Studies
Tomography, Optical Coherence
Visual Acuity
Retinaldehyde

Figure

• 

  Figure 1. Scatter plot of average mGC-IPL difference versus age, IOP at the time of attack, attack duration, spherical equivalent, central corneal thickness and axial length. (A) Correlation between age and average mGC-IPL difference. (B) Correlation between IOP at the time of attack and average mGC-IPL difference. (C) Correlation between attack duration and average mGC-IPL difference. (D) Correlation between spherical equivalent and average mGC-IPL difference. (E) Correlation between central corneal thickness and average mGC-IPL difference. (F) Correlation between axial length and average mGC-IPL difference. MGC-IPL = macular ganglion cell-inner plexiform layer; IOP = intraocular pressure.

Reference

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