J Korean Geriatr Soc.  2004 Sep;8(3):165-169.

Normal Serum Macrophage Migration Inhibitory Factor Concentrations of Korean people According to Age

• Lee JY
• Song SU
• Shin SH

Abstract

BACKGROUND: Macrophage migration inhibitory factor(MIF) was discovered in 1960s as a T-cell cytokine which inhibited random migration of macrophages. MIF is a multifunctional protein acting as cytokine, hormone, or enzyme. It plays a pivotal role in innate and adaptive immune responses and early phase of inflammatory response, as well as cell proliferation, differentiation, and tumor progression. Many inflammatory diseases and cancers show increased activity and serum concentration. The purpose of this study was to measure the normal serum MIF concentration of Korean people to be utilized as base data for future MIF research.
METHODS
Sera of 20 healthy adults from each groups of 20's to 60's(total 100 persons) who visited the Health Promotion center of Inha university Hospital were collected. The MIF concentration in each serum was measured by enzyme-linked immunosorbent assay(ELISA).
RESULTS
The average serum MIF concentration was 1.49 ng/ml(ranging from 0 to 3.33), and there was no significant difference between age groups.
CONCLUSION
The normal serum MIF concentration of Korean people is 1.49 ng/ml, and seems to be unchanged with aging.

Keyword

Macrophage migration inhibitory factor(MIF); Serum concentration; Enzyme-linked immunosorbent assay(ELISA); Korean people

MeSH Terms

Adult
Aging
Cell Proliferation
Health Promotion
Humans
Macrophages*
T-Lymphocytes