J Korean Ophthalmol Soc.
2005 Nov;46(11):1919-1924.
Effect of Triamcinolone Acetonide on the Survival and Nitric Oxide Production in Cultured Human Tenon's Capsule Fibroblasts
- Affiliations
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- 1Department of Ophthalmology, Catholic University of Daegu College of Medicine, Daegu, Korea. jwkim@cu.ac.kr
Abstract
- PURPOSE
To investigate the effect of triamcinolone acetonide (TA) on cell survival and nitric oxide (NO) production in cultured human Tenon's capsule fibroblast (FB) cells. METHODS: After exposed to TA, indomethacin, and dexamethasone for 2 days, cell survival and nitrite production of primarily cultured human FB cells were assessed with MTT and Griess assays, respectively. RESULTS: Cell survival increased after exposure to TA at low concentrations but decreased at high concentrations. TA decreased the production of NO significantly (p<0.05). Exposure to indomethacin and dexamethasone revealed similar results.
CONCLUSIONS
Both the biphasic effect on cell survival and the decreased production of NO induced by TA in FB cells could affect conjunctival wound healing.
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