J Korean Pediatr Soc.  2000 Jul;43(7):978-982.

Two Cases of Thin Basement Membrane Nephropathy presented with Minimal Change Nephrotic Syndrome

• Seo YM
• Chung JG
• Yu ES
• Jeong JY
• Park YS

Abstract

Thin basement membrane nephropathy(TBMN) is defined histologically as follows: 1) By light rnicroscopy only minor abnormalities are detected in the glomeruli at most minor mesangial widening. 2) By electron microscopy, diffuse thinning of glomerular basement rnembrane is demonstrated. 3) By immunofluorescence, absence of immunoglobulins and complement components is demonstrated. 4) Alport's syndrome and systemic diseases that may affect the glomerular structure have been excluded. TBMN presented frequently with recurrent or persistent microscopic hematuria. Massive proteinuria such as in nephrotic syndrome rarely occurs in TBMN. We reported two cases of TBMN presented with typical minimal change nephrotic syndrome.

Keyword

Thin basement membrane nephropathy; Minimal change nephrotic syndrome

MeSH Terms

Basement Membrane*
Complement System Proteins
Fluorescent Antibody Technique
Hematuria
Immunoglobulins
Microscopy, Electron
Nephritis, Hereditary
Nephrosis, Lipoid*
Nephrotic Syndrome
Proteinuria
Complement System Proteins
Immunoglobulins