Korean J Nephrol.
2011 Jan;30(1):94-97.
A Case of Adult Minimal Change Nephrotic Syndrome Associated with Thin Basement Membrane Nephropathy
- Affiliations
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- 1Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea. josephep@paran.com
- 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- Thin basement membrane nephropathy (TBMN) is characterized by persistent hematuria, mild proteinuria, normal renal function and family history of hematuria. Many studies report that TBMN commonly occurs together with other glomerular diseases such as minimal change nephrotic syndrome, membranous nephropathy, IgA nephropathy and focal segmental glomerulosclerosis. Especially, the case of TBMN with minimal change nephrotic syndrome has been rare. We report a case of adult minimal change nephrotic syndrome with TBMN in a 44-year-old female with general edema and microscopic hematuria. On renal biopsy, electron microscopic examination demonstrated diffuse thinning of glomerular basement membrane with the thickness less than 250nm and diffuse foot process effacement. Treatment with corticosteroid resulted in complete remission of proteinuria.
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