Korean J Nephrol.  2010 Jan;29(1):120-124.

A Case of IgA Nephropathy Associated with Thin Basement Membrane Disease

• Lee KM
• Jang JH
• Kim JK
• Oh SE
• Lee DH
• Lee YK
• Noh JW
• Nam ES

Abstract

IgA nephropathy and thin basement membrane disease are common glomerular diseases in persistent microscopic hematuria with or without proteinuria. However, these two conditions cannot be easily distinguished on the biochemical or urinary findings alone. Therefore, renal biopsy is required for correct identification of the two conditions in most cases. Recently, it has been reported that thinning of glomerular basement membrane is accompanied with precipitation of electron dense deposits in some patients with IgA nephropathy. We report a case of IgA nephropathy associated with thin basement membrane disease in a 19-year-old male with microscopic hematuria and mild proteinuria. After 2 years' treatment with angiotensin II receptor blocker, the patient exhibited persistent microscopic hematuria but decreased proteinuria. Our finding concurs with the previous reports indicating that patients with both IgA nephropathy and thin basement membrane disease do not have different clinical features compared to those with IgA nephropathy alone. In addition, clinical outcome does not appear to be affected by thin basement membrane disease when these two conditions are combined.

Keyword

IgA glomerulonephritis; Glomerular basement membrane; Hematuria

MeSH Terms

Basement Membrane
Biopsy
Electrons
Glomerular Basement Membrane
Glomerulonephritis, IGA
Hematuria
Humans
Immunoglobulin A
Male
Proteinuria
Receptors, Angiotensin
Young Adult
Immunoglobulin A
Receptors, Angiotensin