J Korean Soc Biol Psychiatry.  1999 Nov;6(2):189-192.

Antipsychotics Induced Etrapyramidal Symptoms in Schizophrenics in Relation to Cytochrome P450 2D6 Genotype

• Lee MS
• Nam JW

Abstract

The genetically determined CYP2D6 activity may be considered to be associated with antipsychotic induced extrapyramidal side effects with inter-individual variation. Genetic polymorphism of CYP2D6 was determined by polymerase chain reaction(PCR) and Mspl restriction fragment length polymorphisms(RFLP) for 194 schizophrenics. Subjects with a 334bp band were classified a1a1, those with 229bp and 105bp bands a2a2, and those with all three bands a1a2. We did not identify schizophrenic subject with poor metabolizer. 194 schizophrenic patients previously treated neuroleptic medication, were assessed by Extrapyramidal Symptom Rating Scale(ESRS). The cases were composed of 33 akathisia, 47 parkinsonism, 21 tardive dyskinesia. These results are similar to the previous understanding that the poor metabolizer is very rare in Orientals compared to Caucasians, therefore, it considered that CYP2D6 genotypes have maybe no association with schizophrenia and extrapyramidal side effects in Koreans.

MeSH Terms

Antipsychotic Agents*
Cytochrome P-450 CYP2D6*
Cytochrome P-450 Enzyme System*
Cytochromes*
Genotype
Humans
Movement Disorders
Parkinsonian Disorders
Polymorphism, Genetic
Psychomotor Agitation
Schizophrenia
Antipsychotic Agents
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Cytochromes