J Korean Soc Emerg Med.  2012 Feb;23(1):149-153.

Clinical Experiences Treating Edifenphos and Iprobenfos Intoxication Patients

Affiliations
  • 1Department of Emergency Medicine, College of Medicine, Chosun University, Gwangju, Korea. chosooh@naver.com

Abstract

Organophosphate fungicides include edifenphos, iprobenfos and tolclofos-methyl. Edifenphos inhibits cell wall synthesis by reduction in chitin synthase activity and inhibits the action of acetylcholinesterase. Thus, exposure to this chemical results in excessive salivation, lacrimation, urination, defecation, gastrointestinal motility and emesis symptoms, just like other organophosphate insecticides. Although edifenphos is an organophosphate fungicide, it is the only agricultural chemical which inhibits the action of pralidoxime and atropine, an activity which in turn, inhibits treatment. Thus, we have to treat these cases as soon as possible with atropine and pralidoxime, using the same approach as used for exposure to other organophosphate insecticides. In this report we evaluate the results of treatment of 4 patients who were intoxicated by fungicides (3 cases with edifenphos and 1 case with iprobenfos).

Keyword

Fungicides; Edifenphos; Iprobenfos

MeSH Terms

Acetylcholinesterase
Atropine
Cell Wall
Chitin Synthase
Defecation
Gastrointestinal Motility
Humans
Insecticides
Organothiophosphorus Compounds
Pralidoxime Compounds
Salivation
Urination
Vomiting
Acetylcholinesterase
Atropine
Chitin Synthase
Insecticides
Organothiophosphorus Compounds
Pralidoxime Compounds
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