J Korean Diabetes Assoc.  2006 Nov;30(6):459-465.

Effect of Sea Tangle Powder on the Regulation of Blood Glucose Level and Body Weight in Streptozotocin (STZ)-induced Diabetic Rats

• Kim HW
• Kang JS
• Kim SI
• Lee WJ

Abstract

BACKGROUND: Sea tangle is one of the low calorie diet and the fibers in sea tangle suppress the increase of blood glucose level. Therefore, it has a better impact than any other diets for diabetic patients. In the present study, we have investigated the effect of sea tangle powder, hereafter referred as Substance , as an antihyperglycemic agent and antioxidant in streptozotocin (STZ)-induced diabetic rats.
METHODS
Male Wistar rats were divided into three groups: group 1) vehicle-treated normal rats; group 2) vehicle-treated STZ-diabetic rats; group 3) sea tangle powder-treated STZ-diabetic rats. Fasting blood glucose levels and body weights were measured. Intracellular ROS levels were measured using Cytofluor 2350 plate reader.
RESULTS
Oral administration of sea tangle powder for 10 days resulted in lowered levels of blood glucose in early stage (within a week) and preventing effect of weight loss in late stage. Treatment with sea tangle powder resulted in the decrease of intracellular ROS levels in Dendritic Cell line.
CONCLUSION
Sea tangle powder exhibits antihyperglycemic activity and restorative activity on weight loss in STZ-induced diabetic rats. It's abilities depend not on protecting disruption of beta-cell, but on antioxidant effect in other organs.

Keyword

Antioxidant; Diabetes mellitus; Sea tangle powder

MeSH Terms

Administration, Oral
Animals
Antioxidants
Blood Glucose*
Body Weight*
Caloric Restriction
Dendritic Cells
Diabetes Mellitus
Diet
Fasting
Humans
Male
Rats*
Rats, Wistar
Streptozocin*
Weight Loss
Antioxidants
Blood Glucose
Streptozocin

Figure

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  Fig. 1 Schedule for Induction of Diabetes, oral Feeding of Substance and measurement of Fasting blood glucose (FBG) and body weight (B.W).

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  Fig. 2 Effect of Substance on blood glucose levels in early stage. Normal, vehicle-treated rat; DM Control, vehicle-treated STZ-diabetic rat; Substance , Substance -treated STZ-diabetic rats.

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  Fig. 3 Effect of Substance on blood glucose levels in late stage. Normal, vehicle-treated rat; DM Control, vehicle-treated STZ-diabetic rat; Substance , Substance -treated STZ-diabetic rats.

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  Fig. 4 Effect of Substance on body weight loss in diabetic rats. Normal, vehicle-treated rat; DM Control, vehicle-treated STZ-diabetic rat; Substance , Substance -treated STZ-diabetic rats.

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  Fig. 5 Effect of Substance on intracellular ROS levels in normal cells. Negative control, Cell only; Control, Cell + 50 µM DCTH-DA; Substance treated Cell + 50 µM DCTH-DA+ Substance (1 : 200 dilution). Results are representative of three experiments.

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