- Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy
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Park IH, Song YS, Joo HW, Shen GY, Seong JH, Shin NK, Cho YJ, Lee Y, Shin JH, Lim YH, Kim H, Kim KS
- KMID: 2470965
- Diabetes Metab J.
- 2020 Feb;44(1):173-185.
- doi: 10.4093/dmj.2018.0211
BACKGROUND: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated... -
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- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
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Lin S, Yu L, Ni Y, He L, Weng X, Lu X, Zhang C
- KMID: 2470964
- Diabetes Metab J.
- 2020 Feb;44(1):158-172.
- doi: 10.4093/dmj.2018.0235
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated... -
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- Synergistic effects of extracorporeal shockwave therapy and modified Ojayeonjonghwan on erectile dysfunction in an animal model of diabetes
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Jeong HC, Bae WJ, Zhu GQ, Jeon SH, Choi SW, Kim SJ, Cho HJ, Hong SH, Lee JY, Hwang SY, Kim SW
- KMID: 2450546
- Investig Clin Urol.
- 2019 Jul;60(4):285-294.
- doi: 10.4111/icu.2019.60.4.285
PURPOSE: We investigated the synergy effect of extracorporeal shock wave therapy (ESWT) with modified Ojayeonjonghwan (Korean herbal formula, KH-204) in an animal model of diabetes mellitus (DM)-induced erectile dysfunction (ED). MATERIALS... -
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- Poorly-Controlled Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice
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Lee J, Lee HC, Kim SY, Cho GJ, Woodruff T
- KMID: 2450407
- Yonsei Med J.
- 2019 Jul;60(7):667-678.
- doi: 10.3349/ymj.2019.60.7.667
PURPOSE: The aim of this study was to investigate how type I diabetes mellitus (T1D) affects the folliculogenesis and oocyte development, fertilization, and embryo development. MATERIALS AND METHODS: A comparative animal... -
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- The effect of alpha-lipoic acid on expression of VCAM-1 in type 2 diabetic rat
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Ismawati , Mukhyarjon , Asni E, Romus I
- KMID: 2451221
- Anat Cell Biol.
- 2019 Jun;52(2):176-182.
- doi: 10.5115/acb.2019.52.2.176
Macrovascular diabetes complications are generally caused by a process called atherosclerosis. Evidences suggest that to initiate atherosclerosis, oxidated low-density lipoprotein (oxLDL) has to promote the expression of adhesion molecule. Several... -
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- Comparison of Improving Effects for Diabetic Erectile Dysfunction according to the Anti-Glycemic Agents: Phlorizin and Insulin
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Park J, Kwon O, Cho SY, Cho MC, Paick JS, Kim SW
- KMID: 2443236
- World J Mens Health.
- 2019 May;37(2):210-218.
- doi: 10.5534/wjmh.180057
PURPOSE: To compare the improving effects of diabetic erectile dysfunction with two anti-glycemic agents; phlorizin and insulin. MATERIALS AND METHODS: Sixty Sprague-Dawley rats were divided into four groups (n=15 in each... -
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- Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-Methyl-D-Aspartate Receptors
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Ismail CA, Suppian R, Abd Aziz C, Haris K, Long I
- KMID: 2442774
- Diabetes Metab J.
- 2019 Apr;43(2):222-235.
- doi: 10.4093/dmj.2018.0020
BACKGROUND: This study investigated the role of NR2B in a modulated pain process in the painful diabetic neuropathy (PDN) rat using various pain stimuli. METHODS: Thirty-two Sprague-Dawley male rats were randomly... -
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- The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat
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Han JS, Kim SJ, Nam Y, Lee HY, Kim GM, Kim DM, Sohn UD
- KMID: 2432073
- Biomol Ther.
- 2019 Jan;27(1):101-106.
- doi: 10.4062/biomolther.2018.136
Most diabetic patients experience diabetic mellitus (DM) urinary bladder dysfunction. A number of studies evaluate bladder smooth muscle contraction in DM. In this study, we evaluated the change of bladder... -
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- The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease
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Rhee H, Han M, Kim SS, Kim IY, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH
- KMID: 2447161
- Kidney Res Clin Pract.
- 2018 Sep;37(3):222-229.
- doi: 10.23876/j.krcp.2018.37.3.222
BACKGROUND: This study was undertaken to explore the effects of aging on the kidneys in mouse models of diabetes and chronic kidney disease (CKD), and to compare the expression of... -
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- The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats
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Han JS, Min YS, Kim GH, Chae SH, Nam Y, Lee J, Lee SY, Sohn UD
- KMID: 2419007
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):577-584.
- doi: 10.4196/kjpp.2018.22.5.577
Bladder dysfunction is a common complication of diabetes mellitus (DM). However, there have been a few studies evaluating bladder smooth muscle contraction in DM in the presence of pharmacological inhibitors.... -
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- The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats
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Safhi MM, Anwer T, Khan G, Siddiqui R, Moni Sivakumar S, Alam MF
- KMID: 2418999
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):493-501.
- doi: 10.4196/kjpp.2018.22.5.493
The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines... -
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- Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats
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Lee KA, Jin HY, Lee NY, Kim YJ, Park TS
- KMID: 2418722
- Diabetes Metab J.
- 2018 Aug;42(4):338-342.
- doi: 10.4093/dmj.2017.0095
The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic... -
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- Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats
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Koothappan M, Vellai RD, Subramanian IP, Subramanian SP
- KMID: 2413987
- Diabetes Metab J.
- 2018 Jun;42(3):244-248.
- doi: 10.4093/dmj.2018.0002
Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several... -
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- Effects of cinnamic acid on memory deficits and brain oxidative stress in streptozotocin-induced diabetic mice
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Hemmati AA, Alboghobeish S, Ahangarpour A
- KMID: 2410090
- Korean J Physiol Pharmacol.
- 2018 May;22(3):257-267.
- doi: 10.4196/kjpp.2018.22.3.257
The present study aimed to evaluate the cinnamic acid effect on memory impairment, oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model in mice. In this experimental study, 48... -
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- Anti-Diabetic Effect of Cotreatment with Quercetin and Resveratrol in Streptozotocin-Induced Diabetic Rats
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Yang DK, Kang HS
- KMID: 2429052
- Biomol Ther.
- 2018 Mar;26(2):130-138.
- doi: 10.4062/biomolther.2017.254
Quercetin and resveratrol are known to have beneficial effects on the diabetes and diabetic complication, however, the effects of combined treatment of these compounds on diabetes are not fully revealed.... -
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- A comparison of metabolomic changes in type-1 diabetic C57BL/6N mice originating from different sources
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Lee S, Kwak JH, Kim SH, Yun J, Cho JY, Kim K, Hwang D, Jung YS
- KMID: 2459300
- Lab Anim Res.
- 2018 Dec;34(4):232-238.
- doi: 10.5625/lar.2018.34.4.232
Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed... -
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- Hyperglycemia aggravates decrease in alpha-synuclein expression in a middle cerebral artery occlusion model
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Kang JB, Kim DK, Park DJ, Shah MA, Kim MO, Jung EJ, Lee HS, Koh PO
- KMID: 2459295
- Lab Anim Res.
- 2018 Dec;34(4):195-202.
- doi: 10.5625/lar.2018.34.4.195
Hyperglycemia is one of the major risk factors for stroke. Hyperglycemia can lead to a more extensive infarct volume, aggravate neuronal damage after cerebral ischemia. α-Synuclein is especially abundant in... -
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- Growing pigs developed different types of diabetes induced by streptozotocin depending on their transcription factor 7-like 2 gene polymorphisms
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Tu CF, Hsu CY, Lee MH, Jiang BH, Guo SF, Lin CC, Yang TS
- KMID: 2459294
- Lab Anim Res.
- 2018 Dec;34(4):185-194.
- doi: 10.5625/lar.2018.34.4.185
The different polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene promote variances in diabetes susceptibility in humans. We investigated whether these genotypes also promote differences in diabetic susceptibility in... -
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- Effect of Stem Cells and Gene Transfected Stem Cells Therapy on the Pancreas of Experimentally Induced Type 1 Diabetes
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Zickri MB, Aboul-Fotouh GI, Omar AI, El-Shafei , Reda AM
- KMID: 2429553
- Int J Stem Cells.
- 2018 Nov;11(2):205-215.
- doi: 10.15283/ijsc18002
BACKGROUND AND OBJECTIVES: Insulin secretion entirely depends on Ca²⺠influx and sequestration into endoplasmic reticulum (ER) of β-cells, performed by Sarco-ER Ca²âº-ATPase 2b (SERCA2b). In diabetes, SERCA2b is decreased in... -
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- TNF-α Inhibitor Reduces Odontoclast Formation in Diabetes Rats with Ligature-Induced Periodontitis
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Kim JH, Kim AR, Choi YH, Lee DE, Woo GH, Bak EJ, Yoo YJ
- KMID: 2394583
- Int J Oral Biol.
- 2017 Sep;42(3):137-142.
- doi: 10.11620/IJOB.2017.42.3.137
To determine the effect of the tumor necrosis factor-α (TNF-α) in odontoclast formation, we administrated a TNF-α inhibitor in rats with diabetes rats with periodontitis. The rats included in the... -
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