J Korean Cancer Assoc.  2000 Dec;32(6):1122-1132.

The Toxicity of Cisplatin Administered by Isolated Lung Perfusion in Dogs

Affiliations
  • 1Departments of Thoracic and Cardiovascular Surgery, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
  • 2Departments of Diagnostic Pathology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
  • 3Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam University, Daegu, Korea. sshan@medical.yeungnam.ac.kr

Abstract

PURPOSE: This research was designed to evaluate the chronic effect of isolated lung perfusion (ILP) with cisplatin on dogs.
MATERIALS AND METHODS
Fifteen dogs were divided into three groups. Group I was in ILP without cisplatin, group II with 2.5 mg/kg and group III with 5.0 mg/kg of cisplatin for 30 minutes respectively. Serial blood samples were taken before and after ILP for quantitative analysis of serum lactate dehydrogenase (LDH) and blood urea nitrogen/creatinine (BUN/Cr). The specimens from the lung were obtained 2 weeks after ILP.
RESULTS
There were no statistic significant differences in LDH concentration according to the time interval among the groups. The LDH concentration peaked at 1 week after ILP and declined thereafter to the pre-ILP concentration. The concentration of BUN/Cr was in normal range. Histologic examination showed no pathologic change. No significant histopathologic differences were found in the pulmonary parenchyme and vasculature among the groups. All of the dogs survived without complication 2 weeks after ILP.
CONCLUSION
In ILP with cisplatin of 5.0 mg/kg in normal dog, the toxicity of cisplatin itself was not observed. With further study about the technique of ILP with cisplatin it would be effective to deliver high concentration of cisplatin into the target tissue minimizing lung damage.

Keyword

Isolated lung perfusion; Cisplatin; Drug toxicity; Dog
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