J Neurogastroenterol Motil.  2010 Jan;16(1):8-21.

Nonerosive Reflux Disease (NERD) - An Update

  • 1The Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona, USA. Ronnie.Fass@va.gov


Recognizing nonerosive reflux disease (NERD) as a distinct presentation of gastroesophageal reflux disease (GERD) was one of the most important developments in the field of GERD in the last decade. Whilst the definition of NERD has not changed significantly over the years, the disorder accounts for the majority of the GERD patients and those who failed proton pump inhibitor (PPI) treatment. Recent developments in NERD focused primarily on understanding the pathophysiology and natural history. The introduction of esophageal impedance + pH has led to the assessment of other forms of gastroesophageal reflux in causing NERD. Therapeutic modalities still focus on acid suppression, but there is growing recognition that other therapeutic strategies should be considered in NERD.


Nonerosive reflux disease; Gastroesophageal reflux disease; Proton pump inhibitor

MeSH Terms

Electric Impedance
Gastroesophageal Reflux
Hydrogen-Ion Concentration
Natural History
Proton Pumps
Proton Pumps
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