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The Overlap Between GERD and Functional Bowel Disorders - When East Meets Rome

Hershcovici T, Fass R

  • KMID: 2326129
  • J Neurogastroenterol Motil.
  • 2010 Apr;16(2):105-107.
No abstract available.
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Corrigendum: Physicians and Patients Measure Different Dimension on Assessment for Gatroesophageal Reflux Disease-related Symptoms

Lopez-Alvarenga JC, Sobrino-Cossio S, Fass R, Vargas-Romero JA

  • KMID: 2325896
  • J Neurogastroenterol Motil.
  • 2012 Apr;18(2):232-232.
No abstract available.
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Nonerosive Reflux Disease (NERD) - An Update

Hershcovici T, Fass R

  • KMID: 2326112
  • J Neurogastroenterol Motil.
  • 2010 Jan;16(1):8-21.
Recognizing nonerosive reflux disease (NERD) as a distinct presentation of gastroesophageal reflux disease (GERD) was one of the most important developments in the field of GERD in the last decade....
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Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman R, Maradey-Romero C, Gingold-Belfer R, Fass R

  • KMID: 2433470
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):309-319.
  • doi: 10.5056/jnm15105
Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements...
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Current Trends in the Management of Gastroesophageal Reflux Disease

Sandhu DS, Fass R

Gastroesophageal reflux disease (GERD) characterized by heartburn and/or regurgitation symptoms is one of the most common gastrointestinal disorders managed by gastroenterologists and primary care physicians. There has been an increase...
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New and Future Drug Development for Gastroesophageal Reflux Disease

Maradey-Romero C, Fass R

  • KMID: 2381145
  • J Neurogastroenterol Motil.
  • 2014 Jan;20(1):6-16.
Medical therapy remains the most popular treatment for gastroesophageal reflux disease (GERD). Whilst interest in drug development for GERD has declined over the last few years primarily due to the...
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Progression of Jackhammer Esophagus to Achalasia: Author's Reply

Abdallah J, Fass R

  • KMID: 2203591
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):350-350.
  • doi: 10.5056/jnm16052
No abstract available.
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Diagnosis and Management of Functional Chest Pain in the Rome IV Era

Fass R, Shibli F, Tawil J

  • KMID: 2460477
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):487-498.
  • doi: 10.5056/jnm19146
Functional chest pain accounts for about a third of the patients with noncardiac chest pain. It is a very common functional esophageal disorder that remains even today a management challenge...
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Noncardiac Chest Pain: Epidemiology, Natural Course and Pathogenesis

Fass R, Achem SR

  • KMID: 2326204
  • J Neurogastroenterol Motil.
  • 2011 Apr;17(2):110-123.
Noncardiac chest pain is defined as recurrent chest pain that is indistinguishable from ischemic heart pain after a reasonable workup has excluded a cardiac cause. Noncardiac chest pain is a...
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Progression of Jackhammer Esophagus to Type II Achalasia

Abdallah J, Fass R

  • KMID: 2379715
  • J Neurogastroenterol Motil.
  • 2016 Jan;22(1):153-156.
  • doi: 10.5056/jnm15162
It has been suggested that patients with certain motility disorders may progress overtime to develop achalasia. We describe a 66 year-old woman who presented with dysphagia for solids and liquids...
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The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger?

Yamasaki T, Hemond C, Eisa M, Ganocy S, Fass R

  • KMID: 2422846
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):559-569.
  • doi: 10.5056/jnm18140
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is a common disease globally with increasing prevalence and consequently greater burden on the Healthcare system. Traditionally, GERD has been considered a disease of middle-aged...
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Esophageal Hypocontractile Disorders and Hiatal Hernia Size Are Predictors for Long Segment Barrett’s Esophagus

Shibli F, Fass OZ, Teramoto OM, Remes-Troche JM, Rangan V, Kurin M, Fass R

  • KMID: 2537937
  • J Neurogastroenterol Motil.
  • 2023 Jan;29(1):31-37.
  • doi: 10.5056/jnm21255
Background/Aims Presently, there is paucity of information about clinical predictors, especially esophageal motor abnormalities, for long segment Barrett’s esophagus (LSBE) as compared with short segment Barrett’s esophagus (SSBE). The aims of...
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Reflux Hypersensitivity: A New Functional Esophageal Disorder

Yamasaki T, Fass R

  • KMID: 2395417
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):495-503.
  • doi: 10.5056/jnm17097
Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal disorder, is currently considered as the presence of typical heartburn symptoms in patients with normal upper endoscopy and...
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Alteration in Integrated Relaxation Pressure During Successive Swallows in Subjects With Normal Manometry Versus Those With Esophagogastric Junction Outflow Obstruction

Elangovan A, Shibli F, Fass R

  • KMID: 2514675
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):185-190.
  • doi: 10.5056/jnm20139
Background/Aims Integrated relaxation pressure (IRP) is defined as the average minimum esophagogastric junction pressure for 4 seconds of relaxation (contiguous or noncontiguous) within 10 seconds of swallowing. The durability of IRP...
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Role of endoscopy in gastroesophageal reflux disease

Simadibrata DM, Lesmana E, Fass R

In general, gastroesophageal reflux disease (GERD) is diagnosed clinically based on typical symptoms and/or response to proton pump inhibitor treatment. Upper gastrointestinal endoscopy is reserved for patients presenting with alarm...
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Physicians and Patients Measure Different Dimension on Assessment for Gatroesophageal Reflux Disease-Related Symptoms

Lopez-Alvarenga JC, Sobrino-Cossio S, Fass R, Vargas-Romero JA

  • KMID: 2325839
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):381-386.
BACKGROUND/AIMS: Gastroesophageal reflux disease is a highly prevalent disease. Assessing treatment efficacy is critical in that clinical endpoints are properly evaluated. Clinical tools for symptoms severity assessment should be discriminative,...
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The Risk of Acute Myocardial Infarction in Patients With Gastroesophageal Reflux Disease

Eisa M, Sandhu A, Prakash R, Ganocy SJ, Fass R

  • KMID: 2507112
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):471-476.
  • doi: 10.5056/jnm19192
Background/Aims A number of inflammatory mediators have been documented to be elevated in gastroesophageal reflux disease (GERD). Similar inflammatory mediators are involved in coronary artery disease. Thus, the aim of the...
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Comparison of Clinical Characteristics of Patients With Gastroesophageal Reflux Disease Who Failed Proton Pump Inhibitor Therapy Versus Those Who Fully Responded

Dickman R, Boaz M, Aizic S, Beniashvili Z, Fass R, Niv Y

  • KMID: 2325840
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):387-394.
BACKGROUND/AIMS: Refractory gastroesophageal reflux disease (GERD) is very common, affecting up to 40% of the patients receiving proton pump inhibitor (PPI) therapy. However, there is not much information about the...
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Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group

Lopez-Alvarenga JC, Orr W, Vargas-Romero JA, Remes-Troche JM, Morales-Arambula M, Soto-Perez JC, Mateos-Perez G, Sobrino-Cossio S, Teramoto-Matsubara O, Lopez-Colombo A, Orozco-Gamiz A, Saez-Rios , Arellano-Plancarte A, Chiu-Ugalde J, Tholen A, Horbach S, Lundberg L, Fass R

  • KMID: 2381150
  • J Neurogastroenterol Motil.
  • 2014 Jan;20(1):64-73.
BACKGROUND/AIMS: To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms. METHODS: Patients (aged 18-50...
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