J Menopausal Med.  2014 Apr;20(1):39-42.

A Case of Ovarian Steroid Cell Tumor, Not Otherwise Specified, Treated with Surgery and Gonadotropin Releasing Hormone Agonist

• Chung DH
• Lee SH
• Lee KB

Abstract

Steroid cell tumors account for less than 0.1% of all ovarian tumors. There are three steroid cell tumor subtypes: steroid cell tumor not otherwise specified (NOS), stromal luteoma and Leydig cell tumor. Steroid cell tumor, NOS, is the most common type and has malignant potential. This report describes a case of an ovarian steroid cell tumor, NOS. A 35-year-old woman visited hospital with the complaint of metrorrhagia. Physical examination revealed increased pubic hair. Transvaginal ultrasound indentified a 4.9 x 3.4 cm, well-circumscribed and solid left ovarian tumor. After laparoscopic left oophorectomy, the tumor was revealed as an ovarian steroid cell tumor, NOS. During the laparoscopic surgery, tumor ruptured. Complete surgical staging was performed and no evidence of metastasis was found. Gonadotropin releasing hormone agonist was administered monthly for 6 months. The patient has had no evidence of recurrence for 43 months.

Keyword

Gonadotropins; Ovarian neoplasms; Ovary; Sex cord-gonadal stromal tumors; Steroids

MeSH Terms

Adult
Female
Gonadotropin-Releasing Hormone*
Gonadotropins
Hair
Humans
Laparoscopy
Leydig Cell Tumor
Luteoma
Metrorrhagia
Neoplasm Metastasis
Ovarian Neoplasms
Ovariectomy
Ovary
Physical Examination
Recurrence
Sex Cord-Gonadal Stromal Tumors
Steroids
Ultrasonography
Gonadotropin-Releasing Hormone
Gonadotropins
Steroids

Figure

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  Fig. 1 Preoperative transvaginal ultrasonography. Four point nine times three point four cm sized solid tumor at left ovary.

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  Fig. 2 Microscopic photography of steroid cell tumor, not otherwise specified. (A) The tumor consists of irregular cords and nests of large rounded to polygonal cells (H&E, ×100). (B) The cytoplasm of the tumor cells show variable-sized clear vacuoles, representing fat material. Nuclei are monotonous, round and centrally located with prominent nucleoli (H&E, ×400).

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