Endocrinol Metab.  2013 Sep;28(3):221-225. 10.3803/EnM.2013.28.3.221.

Thyroid Dysfunction Associated with Administration of the Long-Acting Gonadotropin-Releasing Hormone Agonist

• Han EJ
• Song HD
• Yang JH
• Park SY
• Kim SH
• Yoon HK
• Yim CH

• KMID: 1973827
• DOI: http://doi.org/10.3803/EnM.2013.28.3.221

Abstract

Gonadotropin-releasing hormone (GnRH) agonist has been used in the treatment of a wide variety of sex-hormone-related diseases, as the administration of GnRH agonist can alter the secretion of gonadotropin and sex hormones. Recently, we found that the long-acting GnRH agonist aggravated hyperthyroidism and induced painless thyroiditis. This is the first report to demonstrate the association of thyroid dysfunction with GnRH agonist injection in Korea. Here, we report three cases and emphasize the clinical importance of this aggravating factor in autoimmune thyroid disease.

Keyword

Gonadotropin-releasing hormone agonist; Graves' disease; Painless thyroiditis

MeSH Terms

Gonadal Steroid Hormones
Gonadotropin-Releasing Hormone
Gonadotropins
Graves Disease
Hyperthyroidism
Korea
Thyroid Diseases
Thyroid Gland
Thyroiditis
Gonadal Steroid Hormones
Gonadotropin-Releasing Hormone
Gonadotropins

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