J Korean Soc Transplant.  2013 Jun;27(2):49-56.

The Effects of Symptom Distress, Social Support, and Work Change on Liver Transplant Recipients

  • 1Department of Nursing, Shinsung University, Dangjin, Korea.
  • 2Department of Surgery, Research Institute for Transplantation, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. transcordi@yuhs.ac


The purpose of this study was to evaluate the factors influencing quality of life (QOL) in liver transplant recipients.
The subjects of this study were 103 liver recipients who received their follow-up more than 3 months after liver transplantation at one general hospital in Seoul. A questionnaire survey was perfomed from September 1, 2012 to September 30, 2012. QOL and factors were evaluated using SF-36, Transplant Symptom Distress Scale and Multidimensional Scale of Perceived Social Support.
Symptom distress, work change after transplant, duration after transplant were significant factors influencing QOL (Cum R2=0.39, F=19.34, P<0.001). Symptom distress was the most important factors related QOL. There were significant differences in QOL according to general characteristics such as education (t=2.16, P=0.033), work change after transplant (t=3.67, P=0.000), duration after transplant (t=2.25, P=0.027), and economic status (t=3.08, P=0.027).
In conclusion, symptom distress had an influence on the QOL of liver transplant recipients. Thus, it is necessary to develop interventions for symptom distress to improve the QOL of liver transplant recipients.


Quality of life; Symptom distress; Liver transplantation

MeSH Terms

Follow-Up Studies
Hospitals, General
Liver Transplantation
Quality of Life
Surveys and Questionnaires


1). Korean Network for Organ Sharing (KONOS). Organ transplant statistics [Internet]. Seoul: KONOS;2011. [cited 2012 Aug 30]. Available from. http://www.konos.go.kr.
2). Tome S, Wells JT, Said A, Lucey MR. Quality of life after liver transplantation. A systematic review. J Hepatol. 2008; 48:567–77.
3). Noma S, Hayashi A, Uehara M, Uemoto S, Murai T. Comparison between psychosocial long-term outcomes of recipients and donors after adult-to-adult living donor liver transplantation. Clin Transplant. 2011; 25:714–20.
4). Kousoulas L, Neipp M, Barg-Hock H, Jackobs S, Strassburg CP, Klempnauer J, et al. Health-related qual-ity of life in adult transplant recipients more than 15 years after orthotopic liver transplantation. Transpl Int. 2008; 21:1052–8.
5). Sainz-Barriga M, Baccarani U, Scudeller L, Risaliti A, Toniutto PL, Costa MG, et al. Quality-of-life assessment before and after liver transplantation. Transplant Proc. 2005; 37:2601–4.
6). Kober B, Küchler T, Broelsch C, Kremer B, Henne-Bruns D. A psychological support concept and quality of life re-search in a liver transplantation program: an interdiscipli-nary multicenter study. Psychother Psychosom. 1990; 54:117–31.
7). Kim EM, Kim KS. A structural model on quality of life for recipients of liver transplants. J Korean Acad Fundam Nurs. 2007; 14:340–50. (김은만, 김금순. 간이식 수혜자의 삶의 질 예측모형. 기본간호학회지 2007;14:340-50.).
8). Kim SY. Health promotion behavior and the quality of life in liver transplant patients [master’s thesis]. Seoul, KR: The Catholic University of Korea;2009. (김소영. 간이식 환자의 건강증진행위와 삶의 질 (석사학위논문). 서울: 가톨릭대학교 보건대학원; 2009.).
9). Kizilisik AT, Grewal HP, Shokouh-Amiri MH, Vera SR, Stratta RJ, Hathaway DK, et al. Ten years of chronic im-munosuppressive therapy following orthotopic liver transplantation: impact on health and quality of life. Transplant Proc. 2001; 33:3448–9.
10). Ware JE Jr, Sherbourne CD. The MOS 36-item short- form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992; 30:473–83.
11). Moons P, De Geest S, Abraham I, Cleemput JV, Van Vanhaecke J. Symptom experience associated with maintenance immunosuppression after heart transplantation: patients' appraisal of side effects. Heart Lung. 1998; 27:315–25.
12). Park MR. Survey on symptom experience and self care in patients with kidney transplantation [master’s thesis]. Seoul, KR: Yonsei University;2003. (박미란. 신장이식 환자의 성별, 이식후 기간별, 면역억제제 종류에 따른 증상경험 및 자가관리 실태조사 (석사학위논문). 서울: 연세대학교 대학원; 2003.).
13). Zimet GD, Dahlem NW, Zimet SG, Farley GK. The multidimensional scale of perceived social support. J Personal Assess. 1988; 52:30–41.
14). Kim SI. A study on social integration of the mental dis-orders attended at day hospital:focus on environmental traits [master’s thesis]. Seoul, KR: Ewha Womans University;1999. (김소임. 낮병원 정신장애인 통합에 관한 연구: 환경특성 중심으로 (석사학위논문). 서울: 이화여자대학교 대학원; 1999.).
15). Desai R, Jamieson NV, Gimson AE, Watson CJ, Gibbs P, Bradley JA, et al. Quality of life up to 30 years following liver transplantation. Liver Transpl. 2008; 14:1473–9.
16). Duffy JP, Kao K, Ko CY, Farmer DG, McDiarmid SV, Hong JC, et al. Long-term patient outcome and quality of life after liver transplantation: analysis of 20-year survivors. Ann Surg. 2010; 252:652–61.
17). Jung JH, Kim YH, Han DJ, Kim KS, Chu SH. Medica-tion adherence in patients taking immunosuppressants after kidney transplantation. J Korean Soc Transplant. 2010; 24:289–97. (정주희, 김영훈, 한덕종, 김광숙, 추상희. 신장이식 환자의 면역억제제 복용이행. 대한이식학회지 2010;24: 289-97.).
18). Kim KS, Kang J, Ha HS, Rho MH, Park KW, Hong JJ. The symptom experience associated with immunosu-ppressive therapy in organ transplant recipients. J Korean Soc Transplant. 2002; 16:110–8. (김금순, 강지연, 하희선, 노명희, 박금화, 홍정자. 장기이식 후 면역 억제제 사용에 따른 증상 경험. 대한이식학회지 2002;16:110-8.).
19). Ham AR. A study on transplant stress and social adjust-ment of liver transplant recipients: with a focus on the moderating effect of social support [master’s thesis]. Seoul, KR: Soongsil University;2012. (함아름. 간이식 수혜자의 이식 스트레스와 사회적응에 관한 연구: 사회적 지지의 조절효과를 중심으로 (석사학위논문). 서울: 숭실대학교 대학원; 2011.).
20). Kim MH, Kim MS, Kwon OJ, Kang CM. Comparison of quality of life between kidney transplant patients and dialysis patients. J Korean Soc Transplant. 2009; 23:65–70. (김명희, 김민수, 권오정, 강종명. 신장이식환자와 투석환자의 삶의 질 비교. 대한이식학회지 2009;23:65-70.).
21). Saab S, Wiese C, Ibrahim AB, Peralta L, Durazo F, Han S, et al. Employment and quality of life in liver transplant recipients. Liver Transpl. 2007; 13:1330–8.
22). Kim HY. Stress and quality of life related to disease following liver transplantation [master’s thesis]. Seoul, KR: The Catholic University of Korea;2003. (김형숙. 간이식 환자의 수술 후 질병관련 스트레스와 삶의 질 (석사학위논문). 서울: 가톨릭대학교 대학원; 2003.).
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