J Korean Acad Rehabil Med.  2001 Aug;25(4):594-600.

The Effects of Botulinum Toxin A on Upper Limb Function in Children with Cerebral Palsy

• Kim HS
• Hwang JH
• Lee PK
• Jung SH
• Park HD
• Cho EH
• Shim JS
• Kim JM

Abstract

OBJECTIVE
To evaluate the efficacy of botulinum toxin type A in the treatment of spasticitc and dystonic upper limbs in a group of cerebral palsy children METHOD: Eighteen children with cerebral palsy who did not have fixed contractures in the wrist and hand were enrolled (mean age 9.0 years; range 6~15). Measurements were obtained before and at 1 and 3 months after botulinum toxin A injections. Assessments included spasticity (modified Ashworth scale), range of motion of thumb and functional assessments including Melbourne assessment of unilateral upper limb function and Jebsen Taylor hand function test. Hand and forearm muscles were injected with 1~3 u/kg botulinum toxin.
RESULTS
Spasticity measured by modified Ashworth scale decreased by 1 month and diminished spasticity continued for 3 months. Range of motion of thumb increased by 1 and 3 months. In Jebsen hand function test, patients showed functional improvements in item 6 (lifting light weight object) and item 7 (lifting heavy object). Melbourne assessment of unilateral upper limb function scores improved from a mean value of 92 at baseline to a mean value of 101 at 1 month and a mean value of 105 at 3 months.
CONCLUSION
Botulinum toxin A would be helpful in some selected cerebral palsy patients with upper limb dysfunction. But further research including randomized controlled study is needed on the use of botulinum toxin A to improve function.

Keyword

Botulinum toxin A; Spasticity; Cerebral palsy; Children; Hand function

MeSH Terms

Botulinum Toxins*
Botulinum Toxins, Type A
Cerebral Palsy*
Child*
Contracture
Forearm
Hand
Humans
Muscle Spasticity
Muscles
Range of Motion, Articular
Thumb
Upper Extremity*
Wrist
Botulinum Toxins
Botulinum Toxins, Type A