J Korean Soc Ther Radiol.  1991 Dec;9(2):249-252.

The Analysis of Failure Pattern in Locally Advanced Stomach Cancer Treated with surgery and Post-Op Chemotherapy: To Explore The Role of Post-Op Irradiation

• Choi EK
• Chang H
• Sun C
• Lee KH
• Lee JS
• Kim SH
• Kim HR
• Kim MH
• Min YI
• Kim JC
• Lee SG
• Park KC

Abstract

A Retrospective study to analyze the failure pattern in locally advanced stomach cancer, trated with radical surgery and post-op chemotherapy was perfomed. Among 107 patients who underwent radical gastrectomy in Asan Mdical Center between June 1989 and August 1990. there were 20 stage II(T2NO,T2N1) and 87 stage III(T3N1,T3N2) and 91 patients were eligible for study. 57 patients treated with 6 cycles of postop adjuvant chemotherapy. A mong 57 patients treated with postop adjuvant chemotherapy, local failure occurred in 21% and distant failure in 12%. Among 34 patients who were not treated with postop chemotherapy, local failure occurred in 24% and distant failure in 26%. Among 29 failures including 13 locoregional, 9 distant metastasis and 7 locoregional and distant metastasis, 11 cases recurred in the anastomotic aite, 3 in the gastric bed, 7 in the regional lymph nodes and peritoneal seeding occurred in 6 cases. The true incidences of gastric bed, nodal and peritoneal failures may be higher in the longer follow-up or reoperative or autopsy series. Our data suggest that postop chemocherapy is beneficial by reducing distant failure rate. Potop adjuvant locoregional radiotherapy in addition to the systemic adjuvant therapy may reduce the local failure rate and potentially benefit in at least 20% of patients who developed the local failure only.

Keyword

Stomach cancer; Chemotherapy; Failure pattern

MeSH Terms

Autopsy
Chemotherapy, Adjuvant
Chungcheongnam-do
Drug Therapy*
Follow-Up Studies
Gastrectomy
Humans
Incidence
Lymph Nodes
Neoplasm Metastasis
Radiotherapy
Retrospective Studies
Stomach Neoplasms*
Stomach*