J Korean Soc Plast Reconstr Surg.  2004 May;31(3):343-350.

Comparison of Wound Healing Effect of Different Forms of Chitosan

Affiliations
  • 1Department of Plastic & Reconstructive Surgery, Daegu Fatima Hospital, Daegu, Korea.
  • 2Department of Plastic & Reconstructive Surgery, Kyungpook University College of Medicine, Daegu, Korea. bccho@knu.ac.kr
  • 3Department of Biochemistry, Kyungpook University College of Medicine, Daegu, Korea.
  • 4Gumi Cha Medical Center, Gumi, Korea.
  • 5Regen Biotech Co., Ltd, Seoul, Korea.

Abstract

This study is to compare the effect of wound healing using three different types of chitin, which include the shapes of sponge, velvet, thick non-woven fabrics, and thin non-woven fabrics. The sponge type had more capacity to absorb the first discharge of a wound than the velvet type and the two non-woven fabrics types. Instead of absorbing the discharge effectively, the velvet type showed a difficulty to take off the dressing stuff from a wound since it was solidly stuck to the wound. The sponge type showed less infiltration of inflammatory cells, producing angiogenesis and fibroblast faster than any other types. Next, the thick non-woven fabrics type was a little more effective than the thin non-woven fabrics type: However, there was no difference between two types. The velvet type sustained the infiltration of inflammatory cells for the longest duration, producing slower angiogenesis and fibroblast. In wound contraction and wound healing, the sponge type was most effective with statistical significance than any other types(p<0.05). The two types of non-woven fabrics did not present any statistical significance in wound contraction, wound epithelization and wound healing(p>0.05). In conclusion, the sponge type showed the best effectiveness to absorb the early discharge, facilitating the progress of inflammatory phase to increase the healing rate. It induced an early healing of wound caused by wound contraction rather than by wound epithelization.

Keyword

Chitosan; Wound healing

MeSH Terms

Bandages
Chitin
Chitosan*
Fibroblasts
Porifera
Wound Healing*
Wounds and Injuries*
Chitin
Chitosan
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