J Korean Soc Pediatr Endocrinol.  2002 Dec;7(2):225-229.

Multifocal Brain Infarction and Intraventricular Hemorrhage in an Infant during Treatment of Diabetic Ketoacidosis

• Son KR
• Kim JS
• Lee HY
• Noh HY
• Back HJ
• Woo YJ

Abstract

Fatal complications including cerebral edema and neurologic collapse occur during treatment of diabetic ketoacidosis(DKA). A 6-week-old female infant with fever, dehydration and drowsy mental status was diagnosed as DKA and neurologically deteriorated during treatment. The cranial computed tomography scan revealed multifocal brain infarctions of the left caudate nucleus, bilateral frontal periventricular white matter, and right parietal cortex. A moderate amount of hemorrhage was also noted in both lateral ventricles. She recovered rapidly with supportive treatment over time. The clinical course and radiologic findings of this patient emphasize the importance of brain infarction as a cause of persistent neurologic loss in children with DKA.

Keyword

Diabetic ketoacidosis; Brain infarction; Neonatal diabetes mellitus

MeSH Terms

Brain Edema
Brain Infarction*
Brain*
Caudate Nucleus
Child
Dehydration
Diabetic Ketoacidosis*
Female
Fever
Hemorrhage*
Humans
Infant*
Lateral Ventricles
Rabeprazole