Tuberc Respir Dis.  2016 Apr;79(2):53-57. 10.4046/trd.2016.79.2.53.

Sepsis and Acute Respiratory Distress Syndrome: Recent Update

Affiliations
  • 1Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sbhong@amc.seoul.kr

Abstract

Severe sepsis or septic shock is characterized by an excessive inflammatory response to infectious pathogens. Acute respiratory distress syndrome (ARDS) is a devastating complication of severe sepsis, from which patients have high mortality. Advances in treatment modalities including lung protective ventilation, prone positioning, use of neuromuscular blockade, and extracorporeal membrane oxygenation, have improved the outcome over recent decades, nevertheless, the mortality rate still remains high. Timely treatment of underlying sepsis and early identification of patients at risk of ARDS can help to decrease its development. In addition, further studies are needed regarding pathogenesis and novel therapies in order to show promising future treatments of sepsis-induced ARDS.

Keyword

Sepsis; Shock, Septic; Acute Respiratory Distress Syndrome; Biomarkers; Treatment; Review

MeSH Terms

Biomarkers
Extracorporeal Membrane Oxygenation
Humans
Lung
Mortality
Neuromuscular Blockade
Respiratory Distress Syndrome, Adult*
Sepsis*
Shock, Septic
Ventilation
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