Tuberc Respir Dis.  2013 Jun;74(6):274-279.

A Case of Pulmonary Sarcoidosis with Endobronchial Nodular Involvement

• Cho KH
• Shin JH
• Park SH
• Kim HS
• Yang SH

Abstract

Sarcoidosis is a multisystemic disorder of unknown cause that is characterized pathologically by noncaseating granulomas. Diagnosis is based on the exclusion of other infectious, interstitial, and neoplastic diseases and on the typical pathology. Although the lungs and mediastinal lymph nodes are almost involved, endobronchial nodular lesions of sarcoidosis with lung involvements are rare. We report a case of sarcoidosis with lung involvements and endobronchial nodules as confirmed by bronchial biopsy.

Keyword

Sarcoidosis; Bronchi; Biopsy

MeSH Terms

Biopsy
Bronchi
Granuloma
Lung
Lymph Nodes
Sarcoidosis
Sarcoidosis, Pulmonary

Figure

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  Figure 1 Chest radiograph showing ill-defined nodular peribronchial lesions in both lungs, most prominently in the mid right and lower lung zones.

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  Figure 2 Chest computed tomography showed consolidation along the right upper and intermediate bronchus and small perilymphatic, centrilobular, and bronchovascular nodules with interlobular septal thickening in the upper right, mid, and lower lobes and the lower left lobe.

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  Figure 3 Follow-up chest radiography and computed tomography showed an increased extent of peribronchial infiltration and air space consolidation, interlobular septal thickening, and ill-defined nodules in both lungs, along with increased size of the multiple enlarged hilar and interlobar lymph nodes.

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  Figure 4 Bronchoscopy showed multiple variable small nodular endobronchial lesions.

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  Figure 5 Biopsy of endobronchial nodules showed diffuse granulomatous inflammation with multinucleated giant cells (H&E stain, ×100).

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  Figure 6 Follow-up chest radiography and computed tomography after treatment with oral steroid showed decreased extent of the peribronchial infiltration and air space consolidation in both lungs, along with a significantly decreased extent of the interlobar septal thickening and perilymphatic or ill-defined nodules, and decreased sizes of the multiple enlarged hilar and interlobar lymph nodes.

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