Yeungnam Univ J Med.  2007 Dec;24(2):252-261.

Association Analyses of beta3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean

• Jung HS
• Lee JH
• Sakong J
• Bae SW
• Kim JH
• Kim JR

Abstract

BACKGROUND: Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors.
MATERIALS AND METHODS
In an attempt to investigate the association of obesity with its candidate genes, beta3 adrenergic receptor (beta3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of beta3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects.
RESULTS
The Trp64Arg polymorphism in the beta3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects.
CONCLUSION
These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the beta3AR Trp64Arg polymorphism.

Keyword

Obesity; Beta-3 adrenergic receptor; Uncoupling protein 2; Polymorphism; Body Mass Index

MeSH Terms

Body Mass Index*
Child
Fasting
Glucose
Humans
Korea
Nutrition Disorders
Obesity
Phenotype
Plasma
Receptors, Adrenergic
Glucose
Receptors, Adrenergic