J Korean Med Sci.  2008 Oct;23(5):776-780. 10.3346/jkms.2008.23.5.776.

Association of UCP1 Genetic Polymorphisms with Blood Pressure among Korean Female Subjects

• Cha MH
• Kang BK
• Suh D
• Kim KS
• Yang Y
• Yoon Y

• KMID: 1783060
• DOI: http://doi.org/10.3346/jkms.2008.23.5.776

Abstract

Recent studies have provided some clues with regard to the relationship existing between uncoupling protein 1 (UCP1) and blood pressure in animal experiments. In an attempt to determine the genetic polymorphisms that are associated with blood pressure in humans, we have analyzed genetic polymorphisms in UCP1 gene. In this study, we assessed the association between UCP1 genotypes and systolic blood pressure (SBP) and diastolic blood pressure (DBP), in a population comprised of 832 Korean female subjects, using a general linear model, which was adjusted for age and body mass index (BMI). Among 4 genetic polymorphisms and the haplotypes constructed from them, haplotype3 of UCP1, UCP1-ht3[GAGA], evidenced significant associations with SBP (p=0.005) and DBP (p=0.013). However, this haplotype was not significantly associated with obesity phenotypes, including BMI or fat mass (p>0.05), thereby suggesting that its association with blood pressure was independent of obesity phenotypes.

Keyword

Mitochondrial Uncoupling Protein; Polymorphism, Genetic; Blood Pressure; Association

MeSH Terms

Adult
Alleles
Blood Pressure
Body Mass Index
Female
Genotype
Haplotypes
Humans
Ion Channels/*genetics
Korea
Mitochondrial Proteins/*genetics
Models, Genetic
Obesity/genetics
Phenotype
*Polymorphism, Genetic

Figure

• 

  Fig. 1 Genetic polymorphisms of the UCP1. (A) Gene map of UCP1 on chromosome 4q28-q31 (Ref. Genome Seq. NT_016354). Coding exons are marked by black blocks and 5' UTRs are marked by white blocks. (B) Common haplotypes constructed from four SNPs. (C) Linkage disequilibrium coefficients among four SNPs.

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