Psychiatry Investig.  2016 May;13(3):333-340. 10.4306/pi.2016.13.3.333.

Effects of Mind-Body Training on Personality and Behavioral Activation and Inhibition System According to BDNF Val66Met Polymorphism

Affiliations
  • 1Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. basuare@daum.net
  • 2Global Cyber University, Cheonan, Republic of Korea.
  • 3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.

Abstract


OBJECTIVE
It has been known that mind-body training (MBT) can affect personality and behavior system as well as emotional well-being, but different effects of MBT on them has not been reported according to BDNF genetic polymorphism.
METHODS
Healthy subjects consisted of 64 subjects and the MBT group who practiced meditation regularly consisted of 72 practitioners. Participants completed neuroticism-extraversion-openness (NEO) Five-Factor Inventory and Behavioral Activation System/Behavioral Inhibition System (BAS/BIS) scales. All subjects were genotyped for the BDNF Val66Met polymorphism.
RESULTS
In the same genotypes of the BDNF Val/Val+Val/Met group, MBT group showed the increased Extraversion (p=0.033) and the increased Openness to Experience (p=0.004) compared to the control group. Also, in the same Met/Met carriers, MBT group exhibited the increase of Extraversion (p=0.008), the reduction of Neuroticism (p=0.002), and the increase of Openness to Experience (p=0.008) compared to the control group. In the same genotypes of the BDNF Val/Val+Val/Met group, MBT group showed the decreased BAS-Reward Responsiveness (p=0.016) and the decrease of BIS (p=0.004) compared to the control group. In the BDNF Met/Met group, MBT group increased BAS-Fun Seeking (p=0.045) and decreased BIS (p=0.013) compared to the control group.
CONCLUSION
MBT would differently contribute to NEO personality and BAS/BIS according to BDNF genetic polymorphism, compensating for different vulnerable traits based on each genotype.

Keyword

Mind-body training; NEO personality; Behavioral activation system; Behavioral inhibition system; BDNF Val66Met genetic polymorphism
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