Psychiatry Investig.  2014 Jan;11(1):76-83.

Association of VAMP-2 and Syntaxin 1A Genes with Adult Attention Deficit Hyperactivity Disorder

• Kenar AN
• Ay OI
• Herken H
• Erdal ME

Abstract

OBJECTIVE
The etiology of attention deficit hyperactivity disorder (ADHD) has not been entirely clarified yet. Structural and metabolic differences at the prefrontal striatal cerebellary system and the interaction of gene and environment are the main factors that thought to play roles in the etiology. Genetic investigations are performed especially about the dopamine pathways and receptors. In this study; it was aimed to investigate the association of the synaptobrevin-2 (VAMP-2) gene Ins/Del polymorphism and syntaxin 1A gene intron 7 polymorphism, which take place in encoding presynaptic protein, with adult ADHD.
METHODS
One hundred thirty-nine patients, having ADHD aging between 18 and 60 years and 106 healthy people as controls were included into the study. DNA samples were extracted from whole blood and genetic analysis were performed.
RESULTS
A significant difference was determined between ADHD and VAMP-2 Ins/Del polymorphism and syntaxin 1A intron 7 polymorphism according to the control group. These polymorphisms were found not to be associated with subtypes of ADHD.
CONCLUSION
It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD.

Keyword

ADHD; VAMP-2; Synaptobrevin 2; Syntaxin 1A; Genetic

MeSH Terms

Adult*
Aging
Attention Deficit Disorder with Hyperactivity*
DNA
Dopamine
Humans
Introns
Qa-SNARE Proteins*
Syntaxin 1*
Vesicle-Associated Membrane Protein 2*
DNA
Dopamine
Qa-SNARE Proteins
Syntaxin 1
Vesicle-Associated Membrane Protein 2