Psychiatry Investig.
2011 Sep;8(3):207-213.
Effect of Initial Ziprasidone Dose on Treatment Outcome of Korean Patients with Acute Manic or Mixed Episodes
- Affiliations
-
- 1Department of Psychiatry, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. wmbahk@catholic.ac.kr
- 2Department of Psychiatry, Bugok National Hospital, Bugok, Korea.
- 3Department of Psychiatry, Naju National Hospital, Naju, Korea.
- 4Department of Psychiatry, Haeundae Paik Hospital and Paik Institute for Clinical Research, Inje University, Busan, Korea.
- 5Department of Neuropsychiatry and Stress Research Institute, Inje University Seoul Paik Hospital, Seoul, Korea.
- 6Department of Psychiatry, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea.
- 7Department of Neuropsychiatry, Konkuk University College of Medicine, Chungju Hospital, Chungju, Korea.
- 8Department of Neuropsychiatry, College of Medicine, Chung-Ang University, Seoul, Korea.
- 9Department of Psychiatry, College of Medicine, Hallym University, Anyang, Korea.
Abstract
OBJECTIVE
We investigated the efficacy and tolerability of ziprasidone combined with divalproex to determine the relationship between the initial dose of ziprasidone and the treatment effect among Korean patients with acute bipolar manic or mixed disorders.
METHODS
This study was a 6-week, open-label, prospective investigation of Korean patients with an acute manic or mixed episode of bipolar disorder. Sixty-five patients were recruited. The patients were categorized based on the initial dose of ziprasidone as follows: low (20-79 mg/day) and standard (80 mg/day). Ziprasidone was given in combination with divalproex in flexible doses, according to the clinical response and tolerability.
RESULTS
The response and remission rates were significantly higher in the standard-dose group than the low-dose group. The combination of ziprasidone and divalproex was well-tolerated and adverse events were mostly mild with no statistically significant increase in body weight.
CONCLUSION
The results of this study showed that a standard starting dose of ziprasidone in combination with divalproex for bipolar disorder is more effective than a low starting dose.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Safety and Efficacy of Ziprasidone: Post-Marketing Surveillance Study in Korea
- Pharmacological Treatment of Major Depressive Episodes with Mixed Features: A Systematic Review
- Re-evaluation of Bipolar Patients Hospitalized for Manic Episode: Possibility of Diagnosing as a Mixed Episode
- A Case of Blonanserin-Induced Mania in Schizophrenia
- Bipolar Disorder
