Korean J Urol.  2011 Sep;52(9):650-652.

Large Oncocytic Adrenocortical Tumor with Uncertain Malignant Potential

• Lee CK
• Choi KH
• Cha YJ
• Jung HB
• Lee HH
• Kim MS
• Park WK
• Yang SC
• Han WK

Abstract

Oncocytoma is a neoplasm consisting of oncocytes that is found in the salivary gland, kidney, and thyroid. Adrenocortical oncocytoma is particularly uncommon, and most cases reported are benign and nonfunctioning. Here, we report a 20 cm adrenal mass associated with necrosis that was identified as an oncocytic adrenocortical tumor with uncertain malignant potential through histopathological evaluation after its resection.

Keyword

Adrenal gland neoplasms; Oxyphil cells; Uncertainty

MeSH Terms

Adenoma, Oxyphilic
Adrenal Gland Neoplasms
Kidney
Necrosis
Oxyphil Cells
Salivary Glands
Thyroid Gland
Uncertainty

Figure

• 

  FIG. 1 (A) Preoperative computed tomography (CT) findings. The CT image shows a huge, mixed solid and cystic mass lesion in the retroperitoneal space (axial view A-1, coronal view A-2). (B) Gross pathology image of the tumor showing a large, multilobulated, mass-like lesion measuring about 20×18.5×9 cm and weighing 1,700 g.

• 

  FIG. 2 (A) Typical structure of an oncocytoma with abundant eosinophilic and granular cytoplasm (H&E, ×100). (B, C) Immunohistochemically, the neoplastic cells were positive for histone H3 phosphorylation and vimentin, respectively.

• 

  FIG. 3 Postoperative whole-body positron emission tomography/computed tomography (PET/CT) scan showing no tumor recurrence (3 months after the operation).

Reference

1. Xiao GQ, Pertsemlidis DS, Unger PD. Functioning adrenocortical oncocytoma: a case report and review of the literature. Ann Diagn Pathol. 2005. 9:295–297.

2. Bisceglia M, Ludovico O, Di Mattia A, Ben-Dor D, Sandbank J, Pasquinelli G, et al. Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol. 2004. 12:231–243.

3. Peppa M, Karamitopoulou E, Nikolopoulos P, Peros G, Economopoulos T, Raptis SA, et al. Large adrenal oncocytoma with uncertain malignant potential: case report and review of literature. Endocr Pract. 2010. 16:641–645.

4. Poretti D, Mazzarol G, Bonomo G, Casadio C, Bellomi M. Adrenocortical oncocytoma: case report. Clin Imaging. 2003. 27:426–430.

5. Ohtake H, Kawamura H, Matsuzaki M, Yokoyama E, Kitajima M, Onizuka S, et al. Oncocytic adrenocortical carcinoma. Ann Diagn Pathol. 2010. 14:204–208.

6. Chang HS, Sohn JC, Park CH, Kim CI, Kwon SY. Adrenocortical Oncocytoma. Korean J Urol. 2007. 48:103–106.

7. Weiss LM. Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol. 1984. 8:163–169.

8. Fukuhara S, Matsuoka Y, Hanafusa T, Nakayama M, Takayama H, Tsujihata M, et al. A case report of prostatic stromal tumor of uncertain malignant potential (STUMP). Hinyokika Kiyo. 2008. 54:377–381.