Obstet Gynecol Sci.  2015 Nov;58(6):530-532. 10.5468/ogs.2015.58.6.530.

Abnormally high level of CA-19-9 in a benign ovarian cyst

Affiliations
  • 1Department Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Korea. diners99@yahoo.co.kr

Abstract

CA-19-9 antigen is mainly elevated in cases of gastrointestinal tract malignancy, including of the pancreas, colorectum, and biliary tract. CA 19-9 antigen can also be elevated in ovarian mucinous neoplasms, however, as well as in many benign conditions. Markedly raised levels of more than 10,000 U/mL were almost observed in advanced stage of malignancy. We report herein the case of a 37-year-old woman who presented with an abnormally high level of CA 19-9 antigen associated with benign mucinous cystadenoma.

Keyword

CA 19-9 antigen; Cystadenoma, mucinous; Tumor markers, biological

MeSH Terms

Adult
Biliary Tract
CA-19-9 Antigen
Cystadenoma, Mucinous
Female
Gastrointestinal Tract
Humans
Mucins
Ovarian Cysts*
Pancreas
Biomarkers, Tumor
CA-19-9 Antigen
Mucins

Figure

  • Fig. 1 Contrast-enhanced computed tomography revealed a bilobulated, enhancing cystic mass in the pelvic cavity.


Reference

1. Berek JS, Bast RC Jr. Ovarian cancer screening: the use of serial complementary tumor markers to improve sensitivity and specificity for early detection. Cancer. 1995; 76:10 Suppl. 2092–2096.
2. Kelly PJ, Archbold P, Price JH, Cardwell C, McCluggage WG. Serum CA19.9 levels are commonly elevated in primary ovarian mucinous tumours but cannot be used to predict the histological subtype. J Clin Pathol. 2010; 63:169–173.
3. Steinberg W. The clinical utility of the CA 19-9 tumorassociated antigen. Am J Gastroenterol. 1990; 85:350–355.
4. Peng D, Xu T, Mason TJ, Wu W. A study of ovarian cancer biomarker amplification using ultrasound for early stage detection. Ultrasonics. 2014; 54:451–454.
5. Cho HY, Kyung MS. Serum CA19-9 as a predictor of malignancy in primary ovarian mucinous tumors: a matched case-control study. Med Sci Monit. 2014; 20:1334–1339.
6. Koprowski H, Herlyn M, Steplewski Z, Sears HF. Specific antigen in serum of patients with colon carcinoma. Science. 1981; 212:53–55.
7. Kudoh K, Kikuchi Y, Kita T, Tode T, Takano M, Hirata J, et al. Preoperative determination of several serum tumor markers in patients with primary epithelial ovarian carcinoma. Gynecol Obstet Invest. 1999; 47:52–57.
8. Atabekoglu C, Bozaci EA, Tezcan S. Elevated carbohydrate antigen 19-9 in a dermoid cyst. Int J Gynaecol Obstet. 2005; 91:262–263.
9. Nanayakkara S, Ali S, Gilmour K. Increased serum carcinomic antigen 19-9(CA 19-9) in a dermoid cyst. J Obstet Gynaecol. 2007; 27:96–97.
10. Madaan M, Puri M, Sharma R, Kaur H, Trivedi SS. Unusually high levels of CA19-9 associated with mature cystic teratoma of the ovary. Case Rep Obstet Gynecol. 2014; 2014:187910.
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