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Necrotizing Fasciitis from a Percutaneous Transhepatic Biliary Drainage Site

Choi J, Cho JT, Choi JY, Jung SN, Seo BF

Percutaneous transhepatic biliary drainage (PTBD) is the established method of treatment for benign or malignant biliary obstruction. Although relatively safe, the procedure is associated with complications including intraperitoneal bile leak,...
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Review of the 2017 European Society of Gastrointestinal Endoscopy Guidelines for Endoscopic Ultrasound - Guided Sampling in Pancreaticobiliary Lesions

Koh DH

EUS currently plays an important role in the diagnosis and treatment of digestive diseases. In addition, EUS-guided sampling has been applied to pancreaticobiliary lesions for the accurate diagnosis of pancreaticobiliary...
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Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts

Luo ZL, Cheng L, Wang T, Tang LJ, Tian FZ, Xiang K, Cui L

BACKGROUND/AIMS: Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile...
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Traumatic bile duct neuroma presenting with acute cholangitis: A case report and review of literature

Lalchandani P, Korn A, Lu JG, French SW, Hou L, Chen KT

Traumatic neuroma of the biliary tree has been previously reported as isolated case reports. In literature, these typically present following prior liver transplant or cholecystectomy, wherein the bile ducts have...
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Safety Evaluation of Paclitaxel-Eluting Biliary Metal Stent with Sodium Caprate in Porcine Biliary Tract

Jang SI, Jeong S, Lee DH, Na K, Yang S, Lee DK

BACKGROUND/AIMS: Metallic stents designed to relieve malignant biliary obstruction are susceptible to occlusive tumor ingrowth or overgrowth. In a previous report, we described metallic stents covered with paclitaxel-incorporated membrane (MSCPM-I,...
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Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer

Nam AR, Jin MH, Park JE, Bang JH, Oh DY, Bang YJ

PURPOSE: The DNA damage response (DDR) is a multi-complex network of signaling pathways involved in DNA damage repair, cell cycle checkpoints, and apoptosis. In the case of biliary tract cancer...
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Clinical Benefit of Maintenance Therapy for Advanced Biliary Tract Cancer Patients Showing No Progression after First-Line Gemcitabine Plus Cisplatin

Hyung J, Kim B, Yoo C, Kim KP, Jeong JH, Chang HM, Ryoo BY

PURPOSE: Gemcitabine plus cisplatin (GemCis) is the standard first-line chemotherapy for patients with advanced biliary tract cancer (BTC). In ABC-02 study, the BTC patients received up to 6-8 cycles of...
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Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer

Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ

PURPOSE: Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun. Jab1 is frequently overexpressed in various cancers and is associatedwith poor prognosis of cancer patients. Thus,...
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Ultrasound-guided transhepatic computed tomography cholecystography in beagle dogs

Kim D, Park S, Kim C, Yoon S, Choi J

This study was performed to evaluate the feasibility of ultrasound-guided computed tomography (CT) cholecystography and to establish an optimal protocol. In 8 healthy beagles, CT cholecystography was conducted using four...
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Dynamics of Soluble Programmed Death-Ligand 1 (sPDL1) during Chemotherapy and Its Prognostic Implications in Cancer Patients: Biomarker Development in Immuno-oncology

Ha H, Bang JH, Nam AR, Park JE, Jin MH, Bang YJ, Oh DY

PURPOSE: The soluble programmed death-ligand 1 (sPDL1) has immunosuppressive activity and is a candidate biomarker for immuno-oncology drug development. In this study, we measured sPDL1 at pre- and post-chemotherapy and...
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Sex and Gender Medicine in Pancreatobiliary Diseases

Park SM

Sex and gender medicine investigates the impact of sex and gender differences on normal conditions, pathogenesis, and clinical features of diseases. By considering sex and gender differences during diagnosis, treatment...
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Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on ¹⁸F-FDOPA PET Imaging

Sater ZA, Jha A, Mandl A, Mangelen S, Carrasquillo JA, Ling A, Gonzales M, Lopes Abath Neto O, Miettinen , Adams KT, Nockel P, El Lakis M, Pacak K

A 36-year-old male patient initially presented with hypertension, tinnitus, bilateral carotid masses, a right jugular foramen, and a periaortic arch mass with an elevated plasma dopamine level but an otherwise...
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A modified single jejunal loop reconstruction by performing proximal gastrojejunostomy after Whipple's pancreticoduodenectomy in a low-volume hospital

Yücesoy A

BACKGROUNDS/AIMS: It is needed to ensure bowel and biliary tract continuity after pancreaticoduodenectomies. It is possible to find a variety of reconstruction methods in literature. METHODS: We realized a modified reconstruction...
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Epidemiology and disease characteristics of symptomatic choledocholithiasis in Sri Lanka

De Silva W, Pathirana , Wijerathne TK, Gamage BD, Dassanayake BK, De Silva M

BACKGROUNDS/AIMS: Published data on choledocholithiasis in Sri Lanka is scarce. This study was conducted to determine epidemiological, clinical and endoscopic characteristics of choledocholithiasis in Sri Lanka. METHODS: This was a retrospective...
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Retrospective analysis of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy of postoperative treatment for biliary tract cancer

Lee HC, Lee JH, Lee SW, Lee JH, Yu M, Jang HS, Kim SH

PURPOSE: This study was conducted to compare the outcome of three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for the postoperative treatment of biliary tract cancer. MATERIALS AND METHODS: From February...
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Long term recurrence free survival in a stage IV gallbladder cancer treated with chemotherapy plus trastuzumab and salvage liver resection

Prieto M, Gastaca M, Ruiz P, Ventoso A, Palomares , Perfecto A, Valdivieso A

Surgery is the only treatment for biliary tract cancer with long term survival. Unfortunately, most patients are diagnosed at stage IV with distant metastases. In these circumstances, life expectancy is...
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Characterization of Intraductal Papillary Neoplasm of the Bile Duct with Respect to the Histopathologic Similarities to Pancreatic Intraductal Papillary Mucinous Neoplasm

Nakanuma Y, Kakuda Y, Uesaka K

Intraductal papillary neoplasms of the bile duct (IPNBs) are known to show various pathologic features and biological behaviors. Recently, two categories of IPNBs have been proposed based on their histologic...
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Percutaneous transhepatic access to allow per-oral enteric stent insertion for malignant duodenal obstruction following failed endoscopic attempt

Ibrahem Adam RE, Thurley P, Pollock G

The treatment options for malignant gastric outlet obstruction include antegrade stent placement or surgical bypass, the latter being associated with a higher level of morbidity and therefore often reserved for...
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Stent-graft placement for treatment of massive hemobilia caused by porto-biliary fistula

Takahashi , Sato Y, Hara K, Okuno N, Dejima I, Murata S, Hasegawa T, Chatani S, Onaya H, Inaba Y

Proton beam therapy is a type of radiation therapy and a promising modality for cancer management because it involves few adverse effects and high therapeutic efficacy. However, there are reports...
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Papillary Cannulation Facilitated by Submucosal Saline Injection into an Intradiverticular Papilla

Lee K, Choi JW, Lee Y, Han JH, Park SM

Endoscopic retrograde cholangiopancreatography (ERCP) of the intradiverticular papilla with its invisible orifice remains challenging. Several techniques have been introduced to evert the papillary opening to facilitate cannulation. A 79-year-old woman...
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