Korean J Urol.  2009 Apr;50(4):401-403.

A Functioning Adrenocortical Oncocytoma

• Oh WS
• Chung JW
• Kwon JB
• Kwon TG
• Kim JS
• Yoon GS

Abstract

Adrenocortical oncocytomas are exceptionally rare and most are benign and nonfunctioning. Only 3 cases of adrenal oncocytomas have been reported in the Korean literature and all of them were nonfunctioning. Herein, we report a case of a functioning adrenocortical oncocytoma in a 49-year-old man who presented with Cushing syndrome.

Keyword

Oxyphilic adenoma; Cushing syndrome

MeSH Terms

Adenoma, Oxyphilic
Cushing Syndrome
Humans
Middle Aged

Figure

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  Fig. 1 Enhanced abdominopelvic computed tomography. A 7.7 cm mass enclosed by a capsule was found on the left adrenal gland (A). Some necrotic tissue was found in the mass (B).

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  Fig. 2 Whole-body positron emission tomography/computed tomography (PET/CT) scan. A 7.7 cm hypermetabolic mass lesion with fluorodeoxyglucose (FDG) uptake was found in the left adrenal gland.

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  Fig. 3 The tumor was grossly well circumscribed with a dark brown color.

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  Fig. 4 Typical structure of an oncocytoma with abundant eosinophilic and granular cytoplasm. Nuclear atypia with enlarged nuclei was found (H&E, ×200).

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  Fig. 5 Electron microscopy. Electron dense inclusion and closely packed mitochondria were found. Some destructed mitochondria with Golgi complex were found (×4,000).

Reference

1. Chang A, Harawi SJ. Oncocytes, oncocytosis, and oncocytic tumors. Pathol Annu. 1992. 27:263–304.

2. Lee SJ, Lee HG, Park CY, Jeong IK, Hong EG, Oh GW, et al. A case of adrenocortical oncocytoma. J Korean Endocrinol. 2004. 19:82–89.

3. Lin BT, Bonsib SM, Mierau GW, Weiss LM, Medeiros LJ. Oncocytic adrenocortical neoplasms: a report of seven cases and review of the literature. Am J Surg Pathol. 1998. 22:603–614.

4. Chang HS, Sohn JC, Park CH, Kim CI, Kwon SY. Adrenocortical oncocytoma. Korean J Urol. 2007. 48:103–106.

5. Geramizadeh B, Norouzzadeh B, Bolandparvaz S, Sefidbakht S. Functioning adrenocortical oncocytoma: a case report and review of literature. Indian J Pathol Microbiol. 2008. 51:237–239.

6. Akatsu T, Kameyama K, Araki K, Ashizawa T, Wakabayashi G, Kitajima M. Functioning adrenocortical oncocytoma: the first documented case producing interleukin-6 and review of the literature. J Endocrinol Invest. 2008. 31:68–73.

7. Gołkowski F, Buziak-Bereza M, Huszno B, Bałdys-Waligórska A, Stefańska A, Budzyński A, et al. The unique case of adrenocortical malignant and functioning oncocytic tumour. Exp Clin Endocrinol Diabetes. 2007. 115:401–404.

8. Xiao GQ, Pertsemlidis DS, Unger PD. Functioning adrenocortical oncocytoma: a case report and review of the literature. Ann Diagn Pathol. 2005. 9:295–297.

9. Erlandson RA, Reuter VE. Oncocytic adrenal cortical adenoma. Ultrastruct Pathol. 1991. 15:539–547.

10. El-Naggar AK, Evans DB, Mackay B. Oncocytic adrenal cortical carcinoma. Ultrastruct Pathol. 1991. 15:549–556.