J Korean Med Sci.  2010 Jul;25(7):1077-1079. 10.3346/jkms.2010.25.7.1077.

Virilizing Adrenocortical Oncocytoma in a Child: A Case Report

• Lim YJ
• Lee SM
• Shin JH
• Koh HC
• Lee YH

• KMID: 1792960
• DOI: http://doi.org/10.3346/jkms.2010.25.7.1077

Abstract

Functioning adrenocortical oncocytomas are extremely rare and most reported patients are 40-60 yr of age. To our knowledge, only 2 cases of functioning adrenocortical oncocytomas have been reported in childhood. We report a case of functioning adrenocortical oncocytoma in a 14-yr-old female child presenting with virilization. She presented with deepening of the voice and excessive hair growth, and elevation of plasma testosterone and dehydroepiandrosterone sulfate. She had an adrenalectomy. The completely resected tumor composed predominantly of oncocytes without atypical mitosis and necrosis. A discussion of this case and a review of the literature on this entity are presented.

Keyword

Adrenal Cortex Neoplasms; Adenoma, Oxyphilic; Virilism; Child

MeSH Terms

Adenoma, Oxyphilic/*complications/metabolism/pathology/surgery
Adolescent
Adrenal Cortex Neoplasms/*complications/metabolism/pathology/surgery
Adrenalectomy
Adult
Female
Humans
Male
Middle Aged
Virilism/*etiology/pathology/surgery

Figure

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  Fig. 1 Excessive hair pattern: (A) chin, (B) lower abdomen.

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  Fig. 2 An abdominal computed tomography (CT) scan showed a 12×12×14 cm-sized, well-circumscribed, huge mass which displace the right kidney anteromedially.

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  Fig. 3 The positron emission tomography (PET) CT scan revealed a heterogeneous hypermetabolic mass which suggested a malignant retroperitoneal or adrenal tumor.

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  Fig. 4 Gross findings of resected tumor. (A) Well-demarcated huge mass, (B) Cut surface of resected tumor showing smooth and glistening surface.

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  Fig. 5 Microscopic findings of resected tumor. (A) The tumor was composed of large cells with eosinophilic cytoplasm. The capsular or sinusoidal invasion was not noted and the subcapsular area showed a compressed normal adrenal cortex. (B) Atypical mitosis and necrosis were absent (H&E, A ×100, B ×400).

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