Kosin Med J.  2013 Jun;28(1):49-54. 10.7180/kmj.2013.28.1.49.

Two Cases of Increased Parasympathetic Nerve System in Irritable Bowel Syndrome with Diarrhea as a Predominant Symptom

  • 1Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea. fmcjs@naver.com


The irritable bowel syndrome(IBS) is a chronic functional gastrointestinal disorder, characterized by abdominal pain, bloating and bowel disturbance. The pathophysiology of IBS is very complicated. Recent studies indicate that the most important mechanisms include visceral hypersensitivity, abnormal gut motility, autonomic nervous system(ANS) dysfunction and disorder of regulation of the brain-gut axis. Patients with IBS frequently present impaired autonomic regulation. Heart rate variability(HRV) is an acknowledged tool for estimating autonomic function. We experienced two cases of increased parasympathetic nervous system by HRV in irritable bowel syndrome with diarrhea as a predominant symptom.


Autonomic nervous system; Heart rate variability; Irritable bowel syndrome

MeSH Terms

Abdominal Pain
Autonomic Nervous System
Axis, Cervical Vertebra
Gastrointestinal Diseases
Heart Rate
Irritable Bowel Syndrome
Parasympathetic Nervous System


  • Fig. 1. Five-minute time & frequency domain indices of heart rate variability (case 1)

  • Fig. 2. Five-minute time & frequency domain indices of heart rate variability (case 2)


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