Korean J Neurogastroenterol Motil.
2008 Jun;14(1):65-70.
A Case of Colonic Hypoganglionosis in Adult
- Affiliations
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- 1Department of Internal Medicine, and Pathology, School of Medicine, Ewha Womans University, Seoul, Korea. jassa@ewha.ac.kr
Abstract
- Hypoganglionosis is a rare form of intestinal neuronal malformation, which is characterized by scarce ganglia and a reduced number of parasympathetic nerves in the intestinal wall. Enteric nervous system can be damaged during postnatal period by ischemic, inflammatory, autoimmunologic process or neurotoxic agent. Acquired hypoganglionosis is usually late onset and characterized as degeneration of ganglion cells and gliosis histologically. We report a case of adult type hypoganglionosis, which is assumed to be an acquired type with the review of literature. The patient with a history of chronic constipation and ileus presented with intestinal obstruction and went on surgical management successfully.
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