Korean J Hematol.  1998 Aug;33(2):273-278.

A Case of Invasive Aspergillosis Involving Lung and Brain in Patient with Acute Leukemia

Affiliations
  • 1Department of Internal Medicine, Kyungpook National University, School of Medicine, Taegu, Korea.

Abstract

Invasive aspergillosis is a life-threatening infectious disease in immunocompromised patients. Aspergillus is an ubiquitous mold present as normal flora in paranasal sinus, nose, skin and lung. The most important determinant of infection is the immune status of the patient, not the intensity of exposure. In acute leukemia and bone marrow transplantation, prolonged neutropenia is probably the most important predisposing factor. We experienced a case of invasive aspergillosis involving lung and brain in patient with acute leukemia during remission-induction chemotherapy. Invasive aspergillosis involving lung and brain was diagnosed by sputum culture, computed tomography (CT) guided lung biopsy and brain magnetic resonance imaging (MRI). Early diagnosis and prompt treatment for invasive aspergillosis are essential for lowering mortality in immunocompromised patients.

Keyword

Invasive Aspergillosis; Lung, Brain; Acute Leukemia

MeSH Terms

Aspergillosis*
Aspergillus
Biopsy
Bone Marrow Transplantation
Brain*
Causality
Communicable Diseases
Drug Therapy
Early Diagnosis
Fungi
Humans
Immunocompromised Host
Leukemia*
Lung*
Magnetic Resonance Imaging
Mortality
Neutropenia
Nose
Skin
Sputum
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