Korean J Hematol.  2007 Sep;42(3):283-287. 10.5045/kjh.2007.42.3.283.

A Case of Immunoglobulin Therapy for Pure Red Cell Aplasia Induced by Parvovirus B19

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Korea. hemonc@hallym.or.kr
  • 2Department of Laboratory Medicine, College of Medicine, Hallym University, Chuncheon, Korea.

Abstract

Human parvovirus B19 infection could be manifested as pure red cell aplasia or chronic anemia in immunocompromised host. The patient was 35-year-old female who had been diagnosed as non-Hodgkin lymphoma, peripheral T-cell unspecified type and had been performed chemotherapy. She complained headache and dizziness that was found to a marked drop in hemoglobin (3.2g/dL). A bone marrow aspiration revealed findings consistent with erythroid hypoplasia with maturation arrest. Serum parvovirus B19 PCR and anti parvovirus B19 IgM were positive. After immunoglobulin therapy, it was leading to a marked increase in reticulocyte count and corresponding rise in hemoglobin. To our knowledge, this is the first report to use immunoglobulin in an adult cancer patient with pure red-cell aplasia. Human parvovirus B19 infection should be considered in immunocompromised cancer patients with red cell aplasia and early use of immunoglobulins would be helpful in resolution of anemia and not to delay planned chemotherapy.

Keyword

Human parvovirus B19; Pure red-cell aplasia; Immunoglobulins

MeSH Terms

Adult
Anemia
Bone Marrow
Dizziness
Drug Therapy
Female
Headache
Humans
Immunization, Passive*
Immunocompromised Host
Immunoglobulin M
Immunoglobulins*
Lymphoma, Non-Hodgkin
Parvovirus B19, Human
Parvovirus*
Polymerase Chain Reaction
Red-Cell Aplasia, Pure*
Reticulocyte Count
T-Lymphocytes
Immunoglobulin M
Immunoglobulins
Full Text Links
  • KJH
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error